Advertisement
Table 5 Summary of meta-analysis outcomes for Japanese type 2 diabetes patients <65 and ≥65 years of age
From: Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis
| Outcome | Effect estimate | 95 % Confidence limits | p value | Effect estimate | 95 % Confidence limits | p value | ||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| <65 years of age | ≥65 years of age | |||||||
| Change in HbA1c (%) | −1.00 | −1.29 | −0.72 | <0.0001 | −1.24 | −1.55 | −0.92 | <0.0001 |
| Change in weight (kg) | −0.15 | −1.07 | 0.76 | 0.74 | −0.58 | −1.39 | 0.22 | 0.16 |
| Change in FPG (mg/dL) | −11.2 | −23.3 | 0.9 | 0.07 | −14.8 | −29.9 | 0.3 | 0.06 |
| Change in PPG: meal test (mg/dL) | −138.1 | −177.0 | −99.2 | <0.0001 | −166.5 | −228.3 | −104.6 | <0.0001 |
| Odds ratio | 95 % Confidence limits | p value | Odds Ratio | 95 % Confidence limits | p value | |||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| <65 years of age | ≥65 years of age | |||||||
| Symptomatic hypoglycemia | 2.3 | 1.0 | 5.6 | 0.06 | 5.1 | 1.3 | 19.7 | 0.0197 |
| Severe hypoglycemia | 0.0 | 0.0 | 0.0 | – | 0.0 | 0.0 | 0.0 | – |
| Endpoint HbA1c <7 % | 13.1 | 3.4 | 50.7 | 0.0002 | 23.2 | 4.1 | 131.9 | 0.0004 |
| Endpoint HbA1c <7 % and no weight gain | 8.4 | 2.1 | 33.8 | 0.0026 | 16.7 | 2.9 | 95.7 | 0.0015 |
| Endpoint HbA1c <7 % and no symptomatic hypoglycemia | 14.0 | 2.6 | 76.8 | 0.0023 | 12.3 | 2.1 | 70.7 | 0.0049 |
| Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia | 7.8 | 1.3 | 45.6 | 0.0221 | 10.1 | 1.7 | 58.3 | 0.0100 |
