Skip to main content

Advertisement

Table 5 Summary of meta-analysis outcomes for Japanese type 2 diabetes patients <65 and ≥65 years of age

From: Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis

Outcome Effect estimate 95 % Confidence limits p value Effect estimate 95 % Confidence limits p value
Lower Upper Lower Upper
<65 years of age ≥65 years of age
Change in HbA1c (%) −1.00 −1.29 −0.72 <0.0001 −1.24 −1.55 −0.92 <0.0001
Change in weight (kg) −0.15 −1.07 0.76 0.74 −0.58 −1.39 0.22 0.16
Change in FPG (mg/dL) −11.2 −23.3 0.9 0.07 −14.8 −29.9 0.3 0.06
Change in PPG: meal test (mg/dL) −138.1 −177.0 −99.2 <0.0001 −166.5 −228.3 −104.6 <0.0001
  1. FPG fasting plasma glucose, PPG postprandial glucose
  Odds ratio 95 % Confidence limits p value Odds Ratio 95 % Confidence limits p value
Lower Upper Lower Upper
<65 years of age ≥65 years of age
Symptomatic hypoglycemia 2.3 1.0 5.6 0.06 5.1 1.3 19.7 0.0197
Severe hypoglycemia 0.0 0.0 0.0 0.0 0.0 0.0
Endpoint HbA1c <7 % 13.1 3.4 50.7 0.0002 23.2 4.1 131.9 0.0004
Endpoint HbA1c <7 % and no weight gain 8.4 2.1 33.8 0.0026 16.7 2.9 95.7 0.0015
Endpoint HbA1c <7 % and no symptomatic hypoglycemia 14.0 2.6 76.8 0.0023 12.3 2.1 70.7 0.0049
Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia 7.8 1.3 45.6 0.0221 10.1 1.7 58.3 0.0100
  1. FPG fasting plasma glucose, PPG postprandial glucose