|
Outcome
|
Effect estimate
|
95 % Confidence limits
|
p value
|
Effect estimate
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
<65 years of age
|
≥65 years of age
|
|---|
|
Change in HbA1c (%)
|
−1.00
|
−1.29
|
−0.72
|
<0.0001
|
−1.24
|
−1.55
|
−0.92
|
<0.0001
|
|
Change in weight (kg)
|
−0.15
|
−1.07
|
0.76
|
0.74
|
−0.58
|
−1.39
|
0.22
|
0.16
|
|
Change in FPG (mg/dL)
|
−11.2
|
−23.3
|
0.9
|
0.07
|
−14.8
|
−29.9
|
0.3
|
0.06
|
|
Change in PPG: meal test (mg/dL)
|
−138.1
|
−177.0
|
−99.2
|
<0.0001
|
−166.5
|
−228.3
|
−104.6
|
<0.0001
|
| |
Odds ratio
|
95 % Confidence limits
|
p value
|
Odds Ratio
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
<65 years of age
|
≥65 years of age
|
|---|
|
Symptomatic hypoglycemia
|
2.3
|
1.0
|
5.6
|
0.06
|
5.1
|
1.3
|
19.7
|
0.0197
|
|
Severe hypoglycemia
|
0.0
|
0.0
|
0.0
|
–
|
0.0
|
0.0
|
0.0
|
–
|
|
Endpoint HbA1c <7 %
|
13.1
|
3.4
|
50.7
|
0.0002
|
23.2
|
4.1
|
131.9
|
0.0004
|
|
Endpoint HbA1c <7 % and no weight gain
|
8.4
|
2.1
|
33.8
|
0.0026
|
16.7
|
2.9
|
95.7
|
0.0015
|
|
Endpoint HbA1c <7 % and no symptomatic hypoglycemia
|
14.0
|
2.6
|
76.8
|
0.0023
|
12.3
|
2.1
|
70.7
|
0.0049
|
|
Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia
|
7.8
|
1.3
|
45.6
|
0.0221
|
10.1
|
1.7
|
58.3
|
0.0100
|
-
FPG fasting plasma glucose, PPG postprandial glucose
