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Table 4 Summary of meta-analysis outcomes for Japanese type 2 diabetes patients with short (<10 years) and long (≥10 years) duration of diabetes

From: Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis

Outcome Effect estimate 95 % Confidence limits p value Effect estimate 95 % Confidence limits p value
Lower Upper Lower Upper
Short (<10 years) duration of diabetes Long (≥10 years) duration of diabetes
Change in HbA1c (%) −1.28 −1.65 −0.91 <0.0001 −0.93 −1.18 −0.67 <0.0001
Change in weight (kg) −0.56 −1.34 0.21 0.16 −0.09 −0.66 0.47 0.75
Change in FPG (mg/dL) −12.7 −26.6 1.2 0.07 −12.6 −24.9 −0.4 0.0438
Change in PPG: meal test (mg/dL) −152.6 −182.0 −123.2 <0.0001 −147.9 −176.8 −119.0 <0.0001
  1. FPG fasting plasma glucose, PPG postprandial glucose
  Odds ratio 95 % Confidence limits p value Odds ratio 95 % Confidence limits p value
Lower Upper Lower Upper
Short (<10 years) duration of diabetes Long (≥10 years) duration of diabetes
Symptomatic hypoglycemia 5.2 1.5 18.7 0.0107 2.1 0.8 5.2 0.11
Severe hypoglycemia 0.0 0.0 0.0 0.0 0.0 0.0
Endpoint HbA1c <7 % 32.1 4.2 246.6 0.0009 8.9 2.5 31.9 0.0008
Endpoint HbA1c <7 % and no weight gain 22.5 2.9 174.3 0.0028 6.3 1.7 23.3 0.0057
Endpoint HbA1c <7 % and no symptomatic hypoglycemia 19.8 2.6 153.5 0.0043 9.0 2.0 41.1 0.0046
Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia 11.6 1.4 93.3 0.0213 7.5 1.6 34.7 0.0099
  1. FPG fasting plasma glucose, PPG postprandial glucose