|
Outcome
|
Effect estimate
|
95 % Confidence limits
|
p value
|
Effect estimate
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
Short (<10 years) duration of diabetes
|
Long (≥10 years) duration of diabetes
|
|---|
|
Change in HbA1c (%)
|
−1.28
|
−1.65
|
−0.91
|
<0.0001
|
−0.93
|
−1.18
|
−0.67
|
<0.0001
|
|
Change in weight (kg)
|
−0.56
|
−1.34
|
0.21
|
0.16
|
−0.09
|
−0.66
|
0.47
|
0.75
|
|
Change in FPG (mg/dL)
|
−12.7
|
−26.6
|
1.2
|
0.07
|
−12.6
|
−24.9
|
−0.4
|
0.0438
|
|
Change in PPG: meal test (mg/dL)
|
−152.6
|
−182.0
|
−123.2
|
<0.0001
|
−147.9
|
−176.8
|
−119.0
|
<0.0001
|
| |
Odds ratio
|
95 % Confidence limits
|
p value
|
Odds ratio
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
Short (<10 years) duration of diabetes
|
Long (≥10 years) duration of diabetes
|
|---|
|
Symptomatic hypoglycemia
|
5.2
|
1.5
|
18.7
|
0.0107
|
2.1
|
0.8
|
5.2
|
0.11
|
|
Severe hypoglycemia
|
0.0
|
0.0
|
0.0
|
–
|
0.0
|
0.0
|
0.0
|
–
|
|
Endpoint HbA1c <7 %
|
32.1
|
4.2
|
246.6
|
0.0009
|
8.9
|
2.5
|
31.9
|
0.0008
|
|
Endpoint HbA1c <7 % and no weight gain
|
22.5
|
2.9
|
174.3
|
0.0028
|
6.3
|
1.7
|
23.3
|
0.0057
|
|
Endpoint HbA1c <7 % and no symptomatic hypoglycemia
|
19.8
|
2.6
|
153.5
|
0.0043
|
9.0
|
2.0
|
41.1
|
0.0046
|
|
Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia
|
11.6
|
1.4
|
93.3
|
0.0213
|
7.5
|
1.6
|
34.7
|
0.0099
|
-
FPG fasting plasma glucose, PPG postprandial glucose
