|
Outcome
|
Effect estimate
|
95 % Confidence limits
|
p value
|
Effect estimate
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
Low (<8 %) baseline HbA1c
|
High (≥8 %) baseline HbA1c
| |
|---|
|
Change in HbA1c (%)
|
−0.80
|
−1.18
|
−0.43
|
<0.0001
|
−1.19
|
−1.46
|
−0.92
|
<0.0001
|
|
Change in weight (kg)
|
−0.62
|
−1.72
|
0.49
|
0.28
|
−0.17
|
−0.68
|
0.34
|
0.52
|
|
Change in FPG (mg/dL)
|
−12.5
|
−30.9
|
5.8
|
0.18
|
−14.7
|
−25.9
|
−3.6
|
0.0097
|
|
Change in PPG: meal test (mg/dL)
|
−132.0
|
−171.7
|
−92.4
|
<0.0001
|
−162.0
|
−185.9
|
−138.1
|
<0.0001
|
| |
Odds ratio
|
95 % Confidence limits
|
p value
|
Odds ratio
|
95 % Confidence limits
|
p value
|
|---|
|
Lower
|
Upper
|
Lower
|
Upper
|
|---|
|
Low (<8 %) baseline HbA1c
|
High (≥8 %) baseline HbA1c
|
|---|
|
Symptomatic hypoglycemia
|
2.9
|
0.8
|
10.0
|
0.10
|
2.9
|
1.2
|
7.1
|
0.0229
|
|
Severe hypoglycemia
|
0.0
|
0.0
|
0.0
|
–
|
0.0
|
0.0
|
0.0
|
–
|
|
Endpoint HbA1c <7 %
|
25.5
|
5.2
|
124.6
|
<0.0001
|
15.8
|
2.9
|
85.6
|
0.0014
|
|
Endpoint HbA1c <7 % and no weight gain
|
15.8
|
3.3
|
75.8
|
0.0005
|
10.0
|
1.8
|
55.9
|
0.0091
|
|
Endpoint HbA1c <7 % and no symptomatic hypoglycemia
|
11.8
|
2.0
|
68.7
|
0.0060
|
11.1
|
2.0
|
61.8
|
0.0059
|
|
Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia
|
8.9
|
1.5
|
52.2
|
0.0154
|
6.4
|
1.1
|
38.6
|
0.0430
|
-
FPG fasting plasma glucose, PPG postprandial glucose
