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Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

Fig. 7

No significant effects of SL or SO diet and DPP-4 inhibitor in insulin-resistant IRS-1 deficient mice. The experiments were performed in IRS-1 deficient (IRS-1−/−) mice after 27 weeks on an SL diet, SO diet, SL + DPP-4 inhibitor (0.4 % des-fluoro-sitagliptin) diet, or SO + DPP-4 inhibitor (0.4 % des-fluoro-sitagliptin) diet. a Body weight gain (n = 6). b Blood glucose levels (n = 6). c Blood glucose levels during insulin tolerance test (ITT) (n = 6). d Blood glucose levels during oral glucose tolerance test (OGTT) (n = 6). e Serum insulin levels during OGTT (n = 6). f β cell mass (n = 6–8). The β cell area is shown as a proportion of the area of the entire pancreas. g Representative pancreatic sections stained with antibodies for insulin (green) and glucagon (red) are shown. The scale bar represent 50 μl. h Quantification of β cell mass as a proportion of the total α-cell-plus-β-cell mass in the islet (n = 6)

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