Table 1 Number (% in parenthesis) or mean values (SD) of clinical variables including circulating biomarkers of a subset of ELSA-Brasil participants, according to tertiles of E-selectin
|  | Tertile1 N = 328 (4.6–55.3 ng/mL) | Tertile 2 N = 328 (55.4–99.2 ng/mL) | Tertile 3 N = 328 (≥99.2 ng/mL) | p valueb | p valuea |
|---|---|---|---|---|---|
Women, n (%) | 196 (59.8) | 180 (54.9) | 170 (48.8) | 0.01 | 0.005 |
Age (years) | 45.3 (5.0) | 46.0 (4.7) | 45.8 (4.9) | 0.616 | 0.743 |
Body mass index (kg/m2) | 25.9 (3.9) | 26.1 (4.1) | 27.2 (4.3) | <0.001c, d | <0.001 |
Waist circumference (cm) | 85.0 (10.9) | 86.1 (11.4) | 90.0 (11.5) | <0.001c, d | <0.001 |
Systolic blood pressure (mmHg) | 115.4 (14.2) | 115.8 (13.9) | 119.4 (15.2) | <0.001c, d | <0.001 |
Diastolic blood pressure (mmHg) | 73.8 (10.1) | 74.2 (10.3) | 77.3 (10.6) | <0.001c, d | <0.001 |
Fasting plasma glucose (mg/dL) | 102.3 (13.3) | 101.9 (8.2) | 103.9 (8.0) | <0.026d | 0.037 |
2-hour plasma glucose (mg/dL) | 118.5 (25.7) | 121.6 (25.2) | 122.1 (27.3) | 0.170 | 0.082 |
HbA1c  % (mmol/mol) | 5.2 [32] | 5.1 [31] | 5.4 (36) | <0.001c, d, e | 0.011 |
Total cholesterol (mg/dL) | 205.4 (36.2) | 208.2 (36.1) | 215.0 (37.2) | 0.003d | 0.001 |
LDL-cholesterol (mg/dL) | 126.9 (30.4) | 127.3 (31.7) | 132.7 (33.5) | 0.037 | 0.021 |
HDL-cholesterol (mg/dL) | 55.7 (13.4) | 56.0 (13.6) | 54.0 (12.6) | 0.130 | 0.170 |
Triglycerides (mg/dL) | 115.1 (64.4) | 126.6 (71.5) | 142.8 (89.1) | <0.001c, d | <0.001 |
Fasting insulinf (µUI/ml) | 5.7 (4.4) | 7.7 (5.6) | 8.5 (6.9) | <0.001d, f | <0.001 |
HOMA-IR | 1.4 (1.2) | 2.0 (1.5) | 2.2 (1.8) | <0.001d, e | <0.001 |
C-reactive proteinf (mg/L) | 1.2 (0.6–2.3) | 1.1 (0.6–2.7) | 1.3 (0.7–3.0) | 0.244 | 0.122 |
IL-6/IL-10 | 4.3 (3.0–5.8) | 4.4 (3.2–5.8) | 4.6 (3.7–5.8) | 0.010c | 0.003 |
TNF-α/IL-10 | 2.7 (3.0–4.9) | 3.7 (3.1–4.5) | 3.8 (3.3–4.7) | 0.044c | 0.012 |