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Table 1 Body weight and fasting blood sugar levels upon L-T2D and E-T2D induction and after a 21-day treatment with chicory, metformin and aspirin

From: Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ− and STZ+ niacinamide-induced diabetes in rats

Parameter Non-diabetic (control) ET2D LT2D
Control CSE-control NIA/STZ CSE- NIA/STZ Met-NIA/STZ STZ CSE-STZ Met-STZ Asp-STZ
Weight (g ± SD)
 Time zero 185.1 ± 4.3 192.8 ± 2.5 241.2 ± 22.1 236.8 ± 30.0 264.3 ± 23.5 248.1 ± 16.7aa 240.4 ± 35.1 260.7 ± 10.4 256.8 ± 17.2
 Diabetes induction, start of treatment (day 10) 192.1 ± 9.2 194.6 ± 6.6 226.8 ± 23.1 248.6 ± 21.1 252.5 ± 26.4 239.1 ± 8.4aaa 232.0 ± 32.5 226.3 ± 16.6*** 238.6 ± 26.3
 End of 21 day treatment time (day 31) 232.1 ± 20.8††,§§ 217.8 ± 12.6††,§ 229.4 ± 15.8 258.3 ± 14.3§ 258.5 ± 19.1 222.8 ± 16.3§ 215.4 ± 32.6§ 231.3 ± 13.3††† 234.8 ± 18.8††
FBS (mg/dl ± SD)
 Time zero 119.5 ± 5.7 111.8 ± 7.5 95.2 ± 6.3aa 99.0 ± 5.8aa 98.8 ± 9.2a 99.3 ± 12.3 108.2 ± 8.4 97.4 ± 5.1aa 98.5 ± 3.9aa
 Diabetes induction, start of treatment (day 10) 111.3 ± 7.3** 107.0 ± 11.6 202.2 ± 8.3aaa,*** 153.0 ± 12.61bb,*** 222.4 ± 9.7aaa,*** 401.5 ± 32.6aaa,*** 346.8 ± 19.5aaa*** 341.0 ± 16.5aaa*** 307.8 ± 7.4aaa,c,***
 End of 21 day treatment time (day 31) 107.8 ± 11.1 103.5 ± 6.1 305.4 ± 88.4†† 82.3 ± 10.2b,††,§§§ 307.4 ± 156.7 398.6 ± 25.5bbb,††† 365.4 ± 44.5††† 371.0 ± 67.9††† 454.8 ± 72.1†††,§§
  1. *, †, and § indicate, respectively, statistically significant differences between time zero vs. day 10; time zero vs. day 31; and day 10 vs. day 31 (single, p < 0.05; double, p < 0.01; triple, p < 0.001). Weights on day 0 for Met-NIA/STZ, STZ, CSE-STZ, and Asp-STZ were significantly higher than control and CSE-control (p < 0.01); for Met-STZ vs. Control and CSE-control, p < 0.001. FBS levels on day 10 in all diabetic groups were significantly higher than Control and CSE-control (p < 0.001)
  2. aSignificant differences between any column vs. Control. bSignificant difference between NIA/STZ vs. CSE-NIA/STZ. cSignificant difference between Asp-STZ vs. STZ (single letters indicate p < 0.05; double letters p < 0.01; and triple letter p < 0.001)