Table 1 Genotype distributions in T2DM patients with (cases) or without DKD (controls)
Polymorphism | Controls (n = 380) | Cases (n = 718) | P | Dominant: OR (95 % CI)/P | Recessive: OR (95 % CI)/P | Additive: OR (95 % CI)/P |
|---|---|---|---|---|---|---|
rs1888747 | ||||||
CC | 10.8 (41) | 6.8 (49) | 0.037 | 0.91 (0.71–1.16)/0.476 | 0.60 (0.39–0.94)/0.031 | 0.60 (0.38–0.95)/0.036 |
CG | 40.0 (152) | 41.5 (298) | ||||
GG | 49.2 (187) | 51.7 (371) | ||||
rs9521445 | ||||||
AA | 18.9 (72) | 22.3 (160) | 0.146 | 0.94 (0.71–1.23)/0.688 | 1.23 (0.90–1.67)/0.226 | 1.12 (0.78–1.61)/0.598 |
AC | 53.2 (202) | 48.5 (348) | ||||
CC | 27.9 (106) | 29.2 (210) | ||||
rs39075 | ||||||
AA | 17.9 (68) | 19.4 (139) | 0.139 | 0.85 (0.66–1.11)/0.264 | 1.10 (0.80–1.52)/0.611 | 0.97 (0.68–1.40)/0.963 |
AG | 49.5 (188) | 44.4 (319) | ||||
GG | 32.6 (124) | 36.2 (260) | ||||
rs451041 | ||||||
AA | 23.4 (89) | 21.3 (153) | 0.318 | 0.86 (0.65–1.13)/0.305 | 0.89 (0.66–1.19)/0.467 | 0.82 (0.58–1.16)/0.296 |
AG | 48.2 (183) | 47.1 (338) | ||||
GG | 28.4 (108) | 31.6 (227) | ||||
rs1041466 | ||||||
GG | 14.2 (54) | 17.3 (124) | 0.059 | 0.87 (0.67–1.13)/0.314 | 1.26 (0.89–1.78)/0.221 | 1.11 (0.76–1.63)/0.659 |
AG | 51.1 (194) | 44.7 (321) | ||||
AA | 34.7 (132) | 38.0 (273) | ||||
rs1411766 | ||||||
AA | 10.0 (38) | 12.6 (91) | 0.399 | 1.25 (0.97–1.60)/0.095 | 1.31 (0.88–1.95)/0.226 | 1.41 (0.93–2.13)/0.131 |
AG | 34.0 (129) | 36.8 (264) | ||||
GG | 56.0 (213) | 50.6 (363) | ||||
rs6492208 | ||||||
CC | 20.7 (79) | 19.9 (143) | 0.461 | 1.01 (0.78–1.31)/1.000 | 0.95 (0.70–1.29)/0.792 | 0.96 (0.68–1.36)/0.898 |
CT | 43.9 (167) | 45.0 (323) | ||||
TT | 35.4 (134) | 35.1 (252) | ||||