|
Variables
|
Baseline
|
Nateglinide
|
p
|
Baseline
|
Rosiglitazone
|
p
|
|---|
|
After 4 months
|
After 4 months
|
|---|
|
Median
|
(25th–75th)
|
Median
|
(25th–75th)
|
Median
|
(25th–75th)
|
Median
|
(25th–75th)
|
|---|
|
Body weight (kg)
|
67.9
|
(64.1–81.0)
|
70.0
|
(64.5–78.0)
|
0.073
|
69.0
|
(63.9–77.0)
|
68.9
|
63.6–77.9
|
0.984
|
|
Hba1c (%)
|
7.45
|
(7.0–8.3)
|
6.65
|
(5.7–7.8)
|
0.032
|
7.2
|
(6.8–8.1)
|
6.6
|
5.5–7.5
|
0.036
|
|
Homa Beta
|
40.7
|
(28.8–52.0)
|
51.3
|
(28.7–73.0)
|
0.126
|
33.6
|
(26.8–59.0)
|
51.6
|
30.9–69.9
|
0.005
|
|
Total-c (mg/dL)
|
223.5
|
(178.5–235.3)
|
194.0
|
(182.0–213.0)
|
0.036
|
213.0
|
(184.0–230.0)
|
211.0
|
201.0–245.0
|
0.277
|
|
HDL-c (mg/dL)
|
44.5
|
(37.8–57–8)
|
44.5
|
(34.0–55.0)
|
0.360
|
45.0
|
(40.0–56.0)
|
48.0
|
38.0–55.0
|
0.347
|
|
LDL-c (mg/dL)
|
144.0
|
(111.0–153.5)
|
131.5
|
(109.5–142.0)
|
0.145
|
152.0
|
(106.0–157.0)
|
142.0
|
124.0–168.0
|
0.355
|
|
CRP (mg/L)
|
5.2
|
(1.87–8.91)
|
3.79
|
(1.63–7.64)
|
0.052
|
4.16
|
(2.23–8.37)
|
3.10
|
(0.87–6.34)
|
0.042
|
|
TGF β (pg/mL)
|
44.1
|
(34.2–51.1)
|
45.3
|
(32.2–49.4)
|
0.247
|
42.7
|
(37.8–47.9)
|
38.3
|
32.0–45.8
|
0.001
|
|
Interleukin-6 (pg/mL)
|
2.54
|
(1.45–5.66)
|
2.37
|
(1.16–3.53)
|
0.108
|
2.71
|
(1.46–4.17)
|
2.00
|
1.42–3.89
|
0.520
|
|
leptina (ng/mL)
|
14.9
|
(7.6–21.0)
|
17.9
|
(10.0–20.8)
|
0.808
|
13.1
|
(6.0–19.3)
|
16.2
|
7.0–24.1
|
0.199
|
|
sICAM-1 (ng/mL)
|
233.8
|
(179.7–261.5)
|
214.9
|
(186.7–263.3)
|
0.391
|
223.6
|
(171.3–241.6)
|
218.0
|
173.8–246.0
|
0.573
|
|
TNF α (pg/mL)
|
1.71
|
(1.18–2.50)
|
1.52
|
(1.08–2.91)
|
0.235
|
1.49
|
(1.23–2.09)
|
1.43
|
1.18–2.18
|
0.760
|
|
fibrinogen (mg/dL)
|
316.0
|
(276.8–375.0)
|
336.5
|
(297.8–357–5)
|
0.433
|
337.0
|
(296–397)
|
322.0
|
(262.5–363.8)
|
0.024
|
|
PA-1 activity (UI/mL)
|
27.7
|
(14.4–43.8)
|
24.7
|
(14.7–40.3)
|
0.55
|
15.9
|
(11.6–40.0)
|
12.7
|
8.0–19.0
|
0.040
|
|
platelet aggregation
|
90.3
|
(80.1–96.0)
|
90.0
|
(81.0–92.6)
|
0.601
|
89.0
|
(76.4–94.5)
|
90.9
|
76.0–95.0
|
0.643
|
- Wilcoxon matched pairs tests were performed to compare the differences before and after the 4 months of therapy for each group
- Italic values indicate statistical significance at p < 0.05
-
CRP reactive protein, HDL-c HDL cholesterol, LDL-c LDL-cholesterol, PAI-1 plasminogen activator inhibitor, sICAM-1 intercellular adhesion molecule-1, TGFβ transforming growth factor beta, TNFα tumor necrosis factor alfa, Total-c total cholesterol
