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TableĀ 2 Expression level of (A) monocyte genes HGF, HGF-R and resistin and (B) serum microRNAs in non-diabetic controls and patients with T2D

From: Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D

Ā 

Non-diabetic controls

T2D

Non-diabetic cont vs. T2D

P value

N

Mean

SEM

N

Mean

SEM

T test

(A) Monocyte genesa

Ā HGF

27

1.00

0.49

32

1.17

0.62

0.03

Ā HGF-R

12

1.00

0.14

10

1.34

0.36

0.40

Ā Resistin

27

1.00

0.43

32

0.47

0.07

0.24

(B) Serum microRNAsb

Ā miR-122

40

1.00

0.15

56

0.86

0.23

0.64

Ā miR-138

13

1.00

0.24

22

0.87

0.17

0.66

Ā miR-146a

40

1.00

0.12

56

0.71

0.06

0.02

Ā miR-155

40

1.00

0.07

55

0.95

0.07

0.65

Ā miR-34c-5p

15

1.00

0.11

23

1.00

0.08

0.96

Ā miR-410

34

1.00

0.12

46

0.92

1.11

0.63

Ā miR-574-3p

37

1.00

0.13

53

0.69

0.07

0.03

Ā miR-576-3p

22

1.00

0.16

36

1.43

0.32

0.31

  1. aGroup size, mean and SEM of HGF, HGF-R and resistin of monocytes. To avoid inter-assay variation, gene levels were expressed in fold change compared to non-diabetic controls, the average of the controls in each assay was set to one (1.00). Differences between groups were tested using independent T test. Levels of significance were set at pĀ =Ā 0.05 (two-tailed). The HGF expression was significantly higher in the monocytes of the patients with T2D as compared to the non-diabetic controls (pĀ =Ā 0.03)
  2. bThis table shows group size, mean and SEM of the fold change values of tested serum microRNAs (reference microRNA sync-cel-mir-39) of the patients with T2D as compared to Non-diabetic controls. Differences between groups were tested using independent T test. Levels of significance were set at pĀ =Ā 0.05 (two-tailed). Serum level of miR-146-a (previously reported [18]) and miR-574-3p, was significantly reduced (pĀ =Ā 0.03) in the T2D sera as compared to the non-diabetic controls when controlling for age, gender, BMI and dyslipidemia