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Table 2 Multinomial logistic regression for the association of CTRP5 (a) WC (b) hip (e), WHR (h) and BMI (k) with outcome risk of NAFLD, T2DM, and NAFLD + T2DM

From: The association of circulating levels of complement-C1q TNF-related protein 5 (CTRP5) with nonalcoholic fatty liver disease and type 2 diabetes: a case–control study

Groups B SE Wald p value Odds ratio 95 % confidence interval for OR Correct prediction (%)
a. Risk of outcomes along with each unit increase in CTRP5
 NAFLD −6.495 0.036 32,216.808 <0.001 0.00151 0.00141–0.00162 40.9
 T2DM −6.571 0.039 28,394.414 <0.001 0.00140 0.00130–0.00151 66.7
 NAFLD + T2DM −6.531 0 0.00146 0.00146–0.001461 26.1
b. Risk of outcomes along with each unit increase in WC
 NAFLD 0.126 0.038 10.756 0.001 1.134 1.052–1.223 22.7
 T2DM 0.071 0.033 4.612 0.032 1.074 1.006–1.146 27.3
 NAFLD + T2DM 0.191 0.044 18.743 <0.001 1.210 1.110–1.319 54.5
c. Adjustment of CTRP5 risk for WC
 NAFLD −6.486 0.039 28,258.994 <0.001 0.00152 0.00141–0.00164 47.6
 T2DM −6.555 0.043 23,663.923 <0.001 0.00142 0.00130–0.00154 52.4
 NAFLD + T2DM −6.522 <0.001 0.001 0.001–0.001 47.4
d. Interaction risk (CTRP5 × WC) for each unit increase in CTRP5 and each unit increase of WC
 NAFLD 0.0 0.0 11.289 0.001 0.999 0.99–1 52.4
 T2DM −0.001 0.0 20.162 <0.001 0.999 0.98–0.99 57.1
 NAFLD + T2DM 0.0 0.0 8.270 0.004 0.999 0.99–1 10.5
e. Risk of outcomes along with each unit increase in hip
 NAFLD 0.169 0.058 8.403 0.004 1.184 1.056–1.327 18.2
 T2DM 0.037 0.049 0.587 0.444 1.038 0.943–1.143 22.7
 NAFLD + T2DM 0.246 0.065 14.306 <0.001 1.279 1.126–1.453 54.5
f. Adjustment of CTRP5 risk for hip
 NAFLD −4.922 0.038 16,351.610 <0.001 0.00728 0.00675–0.00785 47.6
 T2DM −4.994 0.043 13,373.185 <0.001 0.00677 0.00622–0.00737 52.4
 NAFLD + T2DM −4.953 0 <0.001 0.00706 0.00706–0.00706 42.1
g. Interaction risk (CTRP5 × hip) for each unit increase in CTRP5 and each unit increase of hip †
 NAFLD −0.002 0.0005 13.028 <0.001 0.9983 0.9974–0.9992 66.7
 T2DM −0.003 0.001 23.169 <0.001 0.9974 0.9964–0.9984 61.9
 NAFLD + T2DM −0.0002 0.0005 13.013 <0.001 0.9983 0.9973–0.9992 0
h. Risk of outcomes along with each unit increase in WHR
 NAFLD 17.519 6.128 8.171 0.004 40,570,699.7 246.43–6.67 × 1012 63.6
 T2DM 16.808 6.191 7.372 0.007 19,938,468.5 107.2–3.7 × 1012 0
 NAFLD + T2DM 24.517 6.609 13.760 <0.001 44,428,129,710.6 105147.7–1.8 × 1016 57.1
i. Adjustment of CTRP5 risk for WHR
 NAFLD −6.519 0.039 28,193.410 0.001 0.00147 0.00136–0.00159 61.9
 T2DM −6.588 0.041 25,291.299 0.001 0.00137 0.00126–0.00149 42.1
 NAFLD + T2DM −6.559 <0.001 0.00141 0.00141–0.00141 38.9
j. Interaction risk (CTRP5 × WHR) for each unit increase in CTRP5 and each unit increase of WHR
 NAFLD −0.161 0.043 14.026 <0.001 0.851 0.783–0.926 61.9
 T2DM −0.193 0.046 17.424 <0.001 0.824 0.753–0.903 52.6
 NAFLD + T2DM −0.151 0.043 12.6 <0.001 0.860 0.791–0.935 0
k. Risk of outcomes along with each unit increase in BMI
 NAFLD 0.338 0.101 11.155 0.001 1.403 1.150–1.711 31.8
 T2DM 0.173 0.087 3.976 0.046 1.189 1.003–1.409 27.3
 NAFLD + T2DM 0.500 0.117 18.150 <0.001 1.648 1.310–2.074 63.6
l. Adjustment of CTRP5 risk for BMI levels
 NAFLD −4.243 0.038 12,261.550 <0.001 0.0144 0.0133–0.0155 47.6
 T2DM −4.308 0.043 10,259.458 <0.001 0.0134 0.0124–0.0146 57.1
 NAFLD + T2DM −4.283 <0.001 0.0138 0.0138–0.0138 57.9
m. Interaction risk (CTRP5 × BMI) for each unit increase in CTRP5 and each unit increase of BMI
 NAFLD −0.001 0.001 5.166 0.023 0.999 0.997–1.000 57.1
 T2DM −0.003 0.001 14.793 <0.001 0.997 0.996–0.999 61.9
 NAFLD + T2DM 0.000 0.001 2.864 0.091 0.999 0.998–1.000 0
  1. Adjustment for risk of CTRP5 for the aforesaid outcome diseases by controlling for WC (c) hip (f), WHR (i) and BMI (l) The interactive risk of increasing CTRP5 levels with WC (d) hip (g), WHR (j) and BMI (m) for the aforesaid outcome diseases
  2. NAFLD non-alcoholic fatty liver disease, T2DM type 2 diabetes mellitus, CTRP5 complement-C1q TNF-related protein 5, BMI body mass index, WC waist circumference, WHR waist-to-hip ratio
  3. Likelihood Ratio Test: p value < 0.0001