Fig. 8
From: Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
Immunohistochemistry and real-time PCR detect that progesterone replacement inhibits the VEGF-A expression in the diabetic kidney. A Immunohistochemical stain of the kidney sections (hematoxylin staining; magnification, ×400) show that the VEGF-A immunostaining (brown staining) in the glomeruli was much stronger in the D and the D-OVX groups compared with the ND group (arrows). Progesterone replacement inhibited the increase in the VEGF-A immunostaining in D + OVX + P group. B VEGF-A mRNA expression by real-time PCR. Data represent the mean ± SEM. Means with different superscript letters are significantly different from one another (P < 0.05)