DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Table 2 Effect of sitagiliptin on biochemical parameters in plasma and urine of 2K1C rats

Parameters	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	p values
Parameters	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	2K1C	Treatment	Interaction
Plasma
AST (U/L)	26.97 ± 1.25	24.42 ± 0.67	35.27 ± 1.29	27.08 ± 0.58	<0.0001	<0.0001	0.0107
ALT (U/L)	18.32 ± 0.94	20.77 ± 0.76	35.27 ± 1.29	24.35 ± 0.42	0.0002	<0.0001	<0.0001
ALP (U/L)	43.30 ± 1.22	40.83 ± 1.92	56.23 ± 2.49	50.97 ± 1.72	0.0546	<0.0001	0.4697
MDA (nmol/mL)	5.03 ± 0.20	6.58 ± 0.32	8.13 ± 0.24	3.72 ± 0.12	0.0004	<0.0001	0.0630
NO (nmol/mL)	2.82 ± 0.12	3.30 ± 0.31	7.78 ± 0.28	5.20 ± 0.21	0.0003	<0.0001	<0.0001
APOP (ng/mL)	102.45 ± 4.30	129.53 ± 4.73	304.96 ± 10.55	223.33 ± 8.97	0.0019	<0.0001	<0.0001
CATALASE (U/L)	5.42 ± 0.08	5.37 ± 0.13	3.43 ± 0.20	4.05 ± 0.29	0.1532	<0.0001	0.0963
Uric acid (mg/dL)	4.93 ± 0.54	6.24 ± 0.72	12.18 ± 1.15	8.41 ± 0.75	<0.0001	0.1535	0.0070
Creatinin (mg/dL)	1.36 ± 0.10	1.56 ± 0.05	2.30 ± 0.20	1.46 ± 0.31	0.0158	0.1163	0.0446
Urine
Uric acid (mg/dL)	6.25 ± 0.18	4.18 ± 0.25	8.25 ± 0.33	6.78 ± 0.23	<0.0001	<0.0001	0.2536
Creatinin (mg/dL)	10.76 ± 0.54	5.60 ± 0.82	18.90 ± 2.73	7.03 ± 1.18	0.0062	<0.0001	0.0446

Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
APOP advanced protein oxidation product, expressed as nmol/mL equivalent to Chloramine-T
Values are considered significance at p < 0.05

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