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Table 2 Effect of sitagiliptin on biochemical parameters in plasma and urine of 2K1C rats

From: DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Parameters Sham Sham + Sitagliptin 2K1C 2K1C + Sitagliptin p values
2K1C Treatment Interaction
Plasma
 AST (U/L) 26.97 ± 1.25 24.42 ± 0.67 35.27 ± 1.29 27.08 ± 0.58 <0.0001 <0.0001 0.0107
 ALT (U/L) 18.32 ± 0.94 20.77 ± 0.76 35.27 ± 1.29 24.35 ± 0.42 0.0002 <0.0001 <0.0001
 ALP (U/L) 43.30 ± 1.22 40.83 ± 1.92 56.23 ± 2.49 50.97 ± 1.72 0.0546 <0.0001 0.4697
 MDA (nmol/mL) 5.03 ± 0.20 6.58 ± 0.32 8.13 ± 0.24 3.72 ± 0.12 0.0004 <0.0001 0.0630
 NO (nmol/mL) 2.82 ± 0.12 3.30 ± 0.31 7.78 ± 0.28 5.20 ± 0.21 0.0003 <0.0001 <0.0001
 APOP (ng/mL) 102.45 ± 4.30 129.53 ± 4.73 304.96 ± 10.55 223.33 ± 8.97 0.0019 <0.0001 <0.0001
 CATALASE (U/L) 5.42 ± 0.08 5.37 ± 0.13 3.43 ± 0.20 4.05 ± 0.29 0.1532 <0.0001 0.0963
 Uric acid (mg/dL) 4.93 ± 0.54 6.24 ± 0.72 12.18 ± 1.15 8.41 ± 0.75 <0.0001 0.1535 0.0070
 Creatinin (mg/dL) 1.36 ± 0.10 1.56 ± 0.05 2.30 ± 0.20 1.46 ± 0.31 0.0158 0.1163 0.0446
Urine
 Uric acid (mg/dL) 6.25 ± 0.18 4.18 ± 0.25 8.25 ± 0.33 6.78 ± 0.23 <0.0001 <0.0001 0.2536
 Creatinin (mg/dL) 10.76 ± 0.54 5.60 ± 0.82 18.90 ± 2.73 7.03 ± 1.18 0.0062 <0.0001 0.0446
  1. Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
  2. APOP advanced protein oxidation product, expressed as nmol/mL equivalent to Chloramine-T
  3. Values are considered significance at p < 0.05