DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Table 1 Effect of sitagliptin on body weight, food and water intake and organ weight of 2K1C rats

Parameter	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	p values
Parameter	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	2K1C	Treatment	Interaction
Initial body weight (gm)	178.07 ± 6.80	218.40 ± 7.49	214.26 ± 3.39	231.17 ± 11.42	0.0023	0.0073	0.1671
Final body weight (gm)	224.75 ± 14.86	229.55 ± 4.77	269.10 ± 10.56	251.47 ± 12.66	0.5833	0.0095	0.3415
Water intake/d	18.61 ± 1.10	15.69 ± 0.43	20.64 ± 0.72	22.58 ± 0.80	0.5529	<0.0001	0.0074
Liver wet weight	3.24 ± 0.10	3.59 ± 0.24	3.22 ± 0.24	3.72 ± 0.12	0.0310	0.7663	0.6855
Kidney wet weight	1.40 ± 0.07	1.62 ± 0.06	2.36 ± 0.11	2.50 ± 0.18	0.1382	<0.0001	0.7347
Heart wet weight	1.29 ± 0.07	1.45 ± 0.04	1.59 ± 0.05	1.40 ± 0.08	0.0576	0.8114	0.0106
Left ventricle wt.	1.03 ± 0.03	1.06 ± 0.02	1.24 ± 0.07	1.16 ± 0.07	0.0081	0.6402	0.3089
Right ventricle wt.	0.16 ± 0.02	0.23 ± 0.01	0.24 ± 0.02	0.20 ± 0.02	0.1808	0.4152	0.0063
Spleen wet weight	1.37 ± 0.16	1.58 ± 0.16	2.39 ± 0.66	2.00 ± 0.17	0.2505	0.0774	0.1647

Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
Values are considered significance at p < 0.05. (Organ wet weights are expressed as gm/100 gm of body weight)

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