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Table 1 Effect of sitagliptin on body weight, food and water intake and organ weight of 2K1C rats

From: DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Parameter Sham Sham + Sitagliptin 2K1C 2K1C + Sitagliptin p values
2K1C Treatment Interaction
Initial body weight (gm) 178.07 ± 6.80 218.40 ± 7.49 214.26 ± 3.39 231.17 ± 11.42 0.0023 0.0073 0.1671
Final body weight (gm) 224.75 ± 14.86 229.55 ± 4.77 269.10 ± 10.56 251.47 ± 12.66 0.5833 0.0095 0.3415
Water intake/d 18.61 ± 1.10 15.69 ± 0.43 20.64 ± 0.72 22.58 ± 0.80 0.5529 <0.0001 0.0074
Liver wet weight 3.24 ± 0.10 3.59 ± 0.24 3.22 ± 0.24 3.72 ± 0.12 0.0310 0.7663 0.6855
Kidney wet weight 1.40 ± 0.07 1.62 ± 0.06 2.36 ± 0.11 2.50 ± 0.18 0.1382 <0.0001 0.7347
Heart wet weight 1.29 ± 0.07 1.45 ± 0.04 1.59 ± 0.05 1.40 ± 0.08 0.0576 0.8114 0.0106
Left ventricle wt. 1.03 ± 0.03 1.06 ± 0.02 1.24 ± 0.07 1.16 ± 0.07 0.0081 0.6402 0.3089
Right ventricle wt. 0.16 ± 0.02 0.23 ± 0.01 0.24 ± 0.02 0.20 ± 0.02 0.1808 0.4152 0.0063
Spleen wet weight 1.37 ± 0.16 1.58 ± 0.16 2.39 ± 0.66 2.00 ± 0.17 0.2505 0.0774 0.1647
  1. Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
  2. Values are considered significance at p < 0.05. (Organ wet weights are expressed as gm/100 gm of body weight)