Skip to main content


Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Fig. 2

Effect of sitagliptin on kidney inflammation in 2K1C model rats. a Sham; b Sham + Sitagliptin; c 2K1C and d 2K1C + Sitagliptin. No inflammatory process was observed in Sham animals (a) and Sham + Sitagliptin (b). Observe the increase of inflammatory cells in the kidneys of 2K1C (c arrows). Glomerular sclerosis, tubular atrophy with accompanying moderate interstitial fibrosis and infiltration by mononuclear cells was also found. No/less inflammatory process can be observed in right kidney of 2K1C treated with sitagliptin (d). Magnification ×40. H & E staining. ic inflammatory cells, gc glomerular sclerosis

Back to article page