Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus

Table 4 EDN1 and EDNRA haplotype frequencies in patients with type 2 diabetes mellitus according to renal status

Haplotype frequencies	Controls	Cases	P*
EDN1	n = 311	n = 188
T/G	0.752	0.749	0.424
T/T	0.059	0.058
G/G	0.053	0.044
G/T	0.136	0.149
EDNRA	n = 242	n = 276
G/A/A/C/C	0.089	0.072	0.278
G/A/G/C/C	0.057	0.050
G/T/A/T/T	0.100	0.090
A/T/A/T/C	0.273	0.286
A/T/A/T/T	0.178	0.180

The first letter of the END1 haplotype refers to the rs1800541 polymorphism and the second to the rs57072783 polymorphism. The first letter of the EDNRA haplotype refers to the rs4835083 polymorphism, the second to the rs1568136, the third to the rs4639051, the fourth to the 5333 and the last to the rs5343 polymorphism
n number of chromosomes
* P values for comparison of haplotype frequencies between patients with or without diabetic kidney disease were calculated using permutation tests (1000 replications)

ISSN: 1758-5996