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Table 2 Genotypic and allelic frequencies of EDN1 and EDNRA polymorphisms in white type 2 diabetic patients according to renal status

From: Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus

  Genotype frequencies P* OR (95 % CI)   Allele frequencies P**
Controls Cases Controls Cases
EDN1
 rs1800541 n = 304 n = 239       
  TT 200 (65.8) 182 (76.2) 0.031 1 T 0.806 0.866 0.011
  GT 90 (29.6) 50 (20.9)   0.61 (0.41–0.91) G 0.194 0.134  
  GG 14 (4.6) 7 (2.9)   0.55 (0.22–1.39)     
 rs57072783 n = 289 n = 224       
  GG 169 (58.5) 150 (67.0) 0.050 1 T 0.234 0.183 0.062
  TG 105 (36.3) 66 (29.5)   0.71 (0.49–1.03) G 0.766 0.817  
  TT 15 (5.2) 8 (3.6)   0.60 (0.25–1.46)     
EDNRA
 rs4835083 n = 300 n = 233       
  AA 115 (38.3) 100 (42.9) 0.513 1 A 0.622 0.644 0.498
  AG 143 (47.7) 100 (43.9)   0.80 (0.56–1.16) G 0.378 0.356  
  GG 42 (14.0) 33 (14.2)   0.90 (0.53–1.53)     
 rs1568136 n = 308 n = 240       
  TT 149 (47.7) 111 (46.2) 0.852 1 A 0.307 0.323 0.254
  AT 129 (42.1) 103 (42.9)   1.07 (0.75–1.53) T 0.693 0.677  
  AA 30 (10.1) 26 (10.8)   1.16 (0.65–2.08)     
 rs4639051 n = 287 n = 230       
  AA 183 (63.4) 157 (68.3) 0.040 1 A 0.814 0.826 0.113
  AG 103 (35.9) 66 (28.7)   0.75 (0.51–1.09) G 0.186 0.174  
  GG 2 (0.7) 7 (3.0)   4.08 (0.84–19.29)     
 rs5333 n = 284 n = 230       
  TT 137 (48.2) 125 (54.3) 0.373 1 T 0.695 0.728 0.282
  TC 121 (42.6) 85 (37.0)   0.77 (0.53–1.11) C 0.305 0.272  
  CC 26 (9.2) 20 (8.7)   0.84 (0.45–1.59)     
 rs5343 n = 299 n = 235       
  CC 120 (40.1) 105 (43.8) 0.470 1 C 0.698 0.645 0.113
  CT 38 (46.2) 97 (40.9)   2.92 (1.85–4.61) T 0.302 0.355  
  TT 41 (13.7) 36 (15.3)   1.00 (0.60–1.69)     
  1. Genotype frequencies expressed as n (%) and allele frequencies shown as proportions
  2. Bonferroni threshold for multiple comparisons = 0.0071
  3. OR (95 % CI) odds ratio (95 % confidence interval)
  4. * P values computed by Chi square test for genotypes comparisons
  5. ** P values computed by Chi square test for allele frequencies comparisons