Table 2 Genotypic and allelic frequencies of EDN1 and EDNRA polymorphisms in white type 2 diabetic patients according to renal status
Genotype frequencies | P* | OR (95 % CI) | Allele frequencies | P** | ||||
|---|---|---|---|---|---|---|---|---|
Controls | Cases | Controls | Cases | |||||
EDN1 | ||||||||
rs1800541 | n = 304 | n = 239 | ||||||
TT | 200 (65.8) | 182 (76.2) | 0.031 | 1 | T | 0.806 | 0.866 | 0.011 |
GT | 90 (29.6) | 50 (20.9) | 0.61 (0.41–0.91) | G | 0.194 | 0.134 | ||
GG | 14 (4.6) | 7 (2.9) | 0.55 (0.22–1.39) | |||||
rs57072783 | n = 289 | n = 224 | ||||||
GG | 169 (58.5) | 150 (67.0) | 0.050 | 1 | T | 0.234 | 0.183 | 0.062 |
TG | 105 (36.3) | 66 (29.5) | 0.71 (0.49–1.03) | G | 0.766 | 0.817 | ||
TT | 15 (5.2) | 8 (3.6) | 0.60 (0.25–1.46) | |||||
EDNRA | ||||||||
rs4835083 | n = 300 | n = 233 | ||||||
AA | 115 (38.3) | 100 (42.9) | 0.513 | 1 | A | 0.622 | 0.644 | 0.498 |
AG | 143 (47.7) | 100 (43.9) | 0.80 (0.56–1.16) | G | 0.378 | 0.356 | ||
GG | 42 (14.0) | 33 (14.2) | 0.90 (0.53–1.53) | |||||
rs1568136 | n = 308 | n = 240 | ||||||
TT | 149 (47.7) | 111 (46.2) | 0.852 | 1 | A | 0.307 | 0.323 | 0.254 |
AT | 129 (42.1) | 103 (42.9) | 1.07 (0.75–1.53) | T | 0.693 | 0.677 | ||
AA | 30 (10.1) | 26 (10.8) | 1.16 (0.65–2.08) | |||||
rs4639051 | n = 287 | n = 230 | ||||||
AA | 183 (63.4) | 157 (68.3) | 0.040 | 1 | A | 0.814 | 0.826 | 0.113 |
AG | 103 (35.9) | 66 (28.7) | 0.75 (0.51–1.09) | G | 0.186 | 0.174 | ||
GG | 2 (0.7) | 7 (3.0) | 4.08 (0.84–19.29) | |||||
rs5333 | n = 284 | n = 230 | ||||||
TT | 137 (48.2) | 125 (54.3) | 0.373 | 1 | T | 0.695 | 0.728 | 0.282 |
TC | 121 (42.6) | 85 (37.0) | 0.77 (0.53–1.11) | C | 0.305 | 0.272 | ||
CC | 26 (9.2) | 20 (8.7) | 0.84 (0.45–1.59) | |||||
rs5343 | n = 299 | n = 235 | ||||||
CC | 120 (40.1) | 105 (43.8) | 0.470 | 1 | C | 0.698 | 0.645 | 0.113 |
CT | 38 (46.2) | 97 (40.9) | 2.92 (1.85–4.61) | T | 0.302 | 0.355 | ||
TT | 41 (13.7) | 36 (15.3) | 1.00 (0.60–1.69) | |||||