Fig. 3

a Changes in body weight during the experimental period (expressed in %). Values are shown as mean ± SEM. Statistical significance: *p < 0.05 relative to the GK sed group. GK sed sedentary Goto-Kakizaki rats, GK run voluntary wheel-running Goto-Kakizaki rats. b The plasma leptin levels (expressed in ng/L) at the end of the 6-week exercise. Data are mean ± SEM. Statistical significance: *p < 0.05 relative to the GK sed group. GK sed sedentary Goto-Kakizaki rats, GK run voluntary wheel-running Goto-Kakizaki rats