The impact of long-term changes in metabolic status on cardiovascular biomarkers and microvascular endothelial function in middle-aged men: a 25-year prospective study

Table 2 Correlation of traditional metabolic risk factors and reactive hyperemia index to novel CVD biomarkers at follow-up

	WC	HDL-C	SBP	TG	glucose	Uric acid	Reactive hyperemia index
hsCRP, mg/L	0.255**	−0.272**	0.158	0.151	0.068	0.199*	−0.158
Homocysteine, µmol/L	−0.068	−0.038	0.183	0.049	−0.024	0.058	0.017
ox-LDL, ng/mL	0.230*	−0.156	0.171	0.151	0.173	0.106	0.018
sICAM-1, ng/mL	0.111	0.045	0.041	0.053	−0.122	0.161	−0.228*
sVCAM-1, ng/mL	0.095	−0.008	−0.035	−0.011	−0.127	0.039	−0.070
Interleukin-6, pg/mL	0.059	−0.215*	0.157	0.166	0.043	0.075	−0.257*
Leptin, ng/mL	0.193*	−0.171	0.107	0.282**	0.043	0.285**	−0.010
Resistin, ng/mL	−0.025	0.067	0.148	0.021	−0.087	0.027	−0.145
Adiponectin, µmol/L	−0.051	−0.132	−0.148	0.051	−0.089	0.077	0.102
Adiponectin/leptin ratio	−0.177*	0.193*	−0.158	−0.209*	−0.045	−0.222*	0.060
Irisin, µmol/L	0.005	−0.090	−0.124	−0.015	0.017	−0.042	−0.039

WC waist circumference, SBP systolic blood pressure, TG triglycerides, hsCRP high-sensitvity C-reactive protein, sICAM-1 soluble intracellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, ox-LDL oxidized low-density lipoproteins
* p < 0.05; ** p < 0.01; *** p < 0.001

ISSN: 1758-5996