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Table 2 Correlation of traditional metabolic risk factors and reactive hyperemia index to novel CVD biomarkers at follow-up

From: The impact of long-term changes in metabolic status on cardiovascular biomarkers and microvascular endothelial function in middle-aged men: a 25-year prospective study

  WC HDL-C SBP TG glucose Uric acid Reactive hyperemia index
hsCRP, mg/L 0.255** −0.272** 0.158 0.151 0.068 0.199* −0.158
Homocysteine, µmol/L −0.068 −0.038 0.183 0.049 −0.024 0.058 0.017
ox-LDL, ng/mL 0.230* −0.156 0.171 0.151 0.173 0.106 0.018
sICAM-1, ng/mL 0.111 0.045 0.041 0.053 −0.122 0.161 −0.228*
sVCAM-1, ng/mL 0.095 −0.008 −0.035 −0.011 −0.127 0.039 −0.070
Interleukin-6, pg/mL 0.059 −0.215* 0.157 0.166 0.043 0.075 −0.257*
Leptin, ng/mL 0.193* −0.171 0.107 0.282** 0.043 0.285** −0.010
Resistin, ng/mL −0.025 0.067 0.148 0.021 −0.087 0.027 −0.145
Adiponectin, µmol/L −0.051 −0.132 −0.148 0.051 −0.089 0.077 0.102
Adiponectin/leptin ratio −0.177* 0.193* −0.158 −0.209* −0.045 −0.222* 0.060
Irisin, µmol/L 0.005 −0.090 −0.124 −0.015 0.017 −0.042 −0.039
  1. WC waist circumference, SBP systolic blood pressure, TG triglycerides, hsCRP high-sensitvity C-reactive protein, sICAM-1 soluble intracellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, ox-LDL oxidized low-density lipoproteins
  2. * p < 0.05; ** p < 0.01; *** p < 0.001