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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity

Fig. 5

Adipose tissue IRAK-1 mRNA levels correlate with systemic inflammatory or obesity clinical markers. In non-diabetic (49) and diabetic (42) individuals, IRAK-1 gene expression in the adipose tissue was determined using real-time RT-PCR. Plasma levels of representative systemic inflammatory or obesity clinical markers, such as CCL5, C-reactive protein, adiponectin, and triglycerides were determined by using commercial kits and following the manufacturers’ instructions as described in “Patients and methods”. The data show that IRAK-1 mRNA expression in non-diabetic individuals correlated positively/significantly with plasma levels of a CCL5 (r = 0.39, P = 0.02); b C-reactive protein (r = 0.48, P = 0.005); c adiponectin (r = 0.36, P = 0.04); and d triglycerides (r = 0.40, P = 0.02). The IRAK-1 gene expression in diabetic patients did not associate with plasma levels of e CCL5 (r = 0.31, P = 0.09); f C-reactive protein (r = 0.33, P = 0.07); and g adiponectin (r = 0.01, P = 0.90) but it correlated significantly with h triglyceride levels (r = −0.36, P = 0.04). Notably, the IRAK-1 correlation data are shown for 32 non-diabetic and 30 diabetic individuals as missing plasma data necessitated exclusion of the relevant individuals from correlation analysis

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