Fig. 4

Increased IRAK-1 gene expression correlates with adipose tissue infiltration by monocytes/macrophages. The adipose tissue gene expression of IRAK-1 and selective monocytes/macrophage markers including CD68, CD11c, and CD163 was determined in 49 non-diabetic and 42 diabetic individuals by using real-time RT-PCR. The data show that IRAK-1 gene expression in non-diabetic individuals correlated positively/significantly with a CD68 (r = 0.32, P = 0.02); b CD11c (r = 0.30, P = 0.03); and c CD163 (r = 0.43, P = 0.001). IRAK-1 gene expression in diabetic patients did not associate with d CD68 (r = 0.10, P = 0.50) and e CD11c (r = 0.25, P = 0.10); however, it correlated significantly with f CD163 expression (r = 0.34, P = 0.02)