Effects of caloric restriction and low glycemic index diets associated with metformin on glucose metabolism and cortisol response in overweight/obese subjects: a case series study

Table 1 Cortisol levels in basal conditions and after suppression by dexamethasone; glucocorticoid receptors in lymphocytes and monocytes at baseline and 16 weeks after a hypocaloric low glycemic index diet and metformin use in 16 subjects

Variables	Baseline		16 weeks		Δ	p ^a
Variables	Mean	SD	Mean	SD	Δ	p ^a
Basal cortisol (μg/dL)	7.19 ^b	3.35	8.69 ^c	4.55	1.50	0.24
Post-dexamethasone cortisol (μg/dL)	4.27 ^b	2.85	5.99 ^c	5.31	1.72	0.02
Glucocorticoid receptors ^d	23,390	8052	26,650	9408	3260	0.66

Data are expressed as mean and standard deviation (SD)
^a16 weeks vs. basal = paired Student t test
^bp < 0.001 basal cortisol vs. post-dexamethasone cortisol = paired Student t test
^c p = 0.01 basal cortisol vs. post-dexamethasone cortisol = Wilcoxon test
^d n = 6 subjects (4 male, 2 female)

ISSN: 1758-5996