Fig. 2

Cellular Regulation of Human Resistin. Activation of gene transcription of human resistin is mediated by intracellular signalling cascades generated through activation of either TNF receptor α, or through TLR4 activation. Exocytotic secretory processes release resistin into the extracellular environment. Resistin is postulated to bind to and activate TLR4, potentially resulting in autoregulation of resistin secretion through a positive feedback mechanism, and/or result in the upregulation of expression of inflammatory cytokines. Alternatively, resistin has been postulated to bind to and activate CAP-1. The resultant elevation of cAMP induces NF-κB gene expression, mediated by PKA, resulting in the expression of inflammatory cytokines. Internalization of resistin may occur through endocytotic processes