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Table 4 Relationship of HSD11B1 gene polymorphic variants with obesity, the metabolic syndrome, and diabetes: studies and subjects’ characteristics

From: Association of HSD11B1 polymorphic variants and adipose tissue gene expression with metabolic syndrome, obesity and type 2 diabetes mellitus: a systematic review

Author, year

Subjects’ characteristics

T2DM

BMI (kg/m 2 )

MetS

HSD11B1 polymorphisms

Association with metabolic parameters

Franks, 2004 [30]

n: 918

512 (55.8)

32.7 (28 – 38)

N/D

rs846910 and rs12086634

No association with obesity and diabetes

Age: 36 (28 – 46)

 

Ethnicity: American Indian

     

Nair, 2004 [35]

n: 706 (SNP1), 839 (SNP5)

SNP1: 429 (60.8)

N/D

N/D

SNP1 (rs846910 and rs3334312)

SNP1 – OR = 1.64; P = 0.01

SNP5: 510 (60.8)

SNP5 (N/D, rs12086634 and rs6752)

SNP5 – OR = 1.34; P = 0.02

For T2DM (+) vs. T2DM (−)

 

Age: N/D

     
 

Ethnicity: Pima Indian

     

Robitaille, 2004 [36]

n: 217

N/D

29.6 ± 4.3

N/D

4478 T > G, 4437–4438insA and 10733G > C

No association with BMI, WC, HDL-c, TG, FPG, fasting insulin, BP, HOMA-IR

Age: 42.8 ± 7.9

Ethnicity: French-Canadian

Miyamoto, 2009 [33]

n: 3005

N/D

22.8 ± 2.7

431 (14.3)

rs860185, −658G > A, +1930insA, rs12086634, rs2236905, rs2298930, rs932335 and rs6752

No association with MetS

Age:65.8 ± 10.3

Ethnicity: Japanese

Ku, 2009 [32]

n: 1401

757 (54.0)

24.1 ± 3.0

N/D

rs45441700, rs846908, rs701950, +1932Ginsdel, xrs932335, rs13306422, rs6752 and +30249 T > C

No association with WHR, BMI, FPG, HbA1c, fasting insulin, and HOMA-IR

Age: 61.8 ± 7.2

Ethnicity: Korean

Moon, 2011 [34]

n: 785

427 (54.4)

23.3 ± 0.2

N/D

rs12086634 and rs1000283

No association with T2DM and MetS

Age: 62.2 ± 0.5

Ethnicity: Korean

Dujic, 2012 [29]

n: 86

N/D

28.9 (25.7 – 31.5)

43 (50.0)

rs846910 and rs45487298

rs846910 related with ↓ HOMA-IR; P = 0.011a

Age: 47 (40 – 53)

rs45487298 related with ↓ HOMA-IR; P = 0.04b

 

Ethnicity: Bosnian

     

Gandhi, 2013 [31]

n: 205

62 (30.2)

25.7 ± 2.9

105 (51.2)

rs12086634

Associated with MetS (OR = 6.64; P < 0.0001)

Age: 43 ± 11.5

Ethnicity: South Indian

Turek, 2014 [37]

n: 215

N/D

26.5 ± 4.5

N/D

rs846910 and rs12086634

rs846910 not related with BMI and FPG

Age: N/D (22 – 72)

rs12086634 not related with FPG; P = 0.06

 

Ethnicity: Euro-Brazilian

     
  1. Data expressed as absolute and relative frequencies, median (interquartile range), or mean ± standard deviation as appropriate. N/D: not described; T2DM: type 2 diabetes mellitus; BMI: body mass index; MetS: metabolic syndrome; WC: waist circumference; HDL-c: HDL cholesterol; TG: triglycerides; FPG: fasting plasma glucose; BP: blood pressure; HOMA-IR: homeostatic model assessment of insulin resistance; HbA1c: glycated hemoglobin A1c; NPG: non-polymorphic group; PG: polymorphic group. ain MetS (+) group. bin control group.