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Table 3 Relationship between HSD11B1 gene expression in abdominal adipose tissue and obesity: studies and subjects’ characteristics

From: Association of HSD11B1 polymorphic variants and adipose tissue gene expression with metabolic syndrome, obesity and type 2 diabetes mellitus: a systematic review

Author, year

Subjects’ characteristics

T2DM

Obesity

BMI (kg/m 2 )

MetS

Expression in VAT

Expression in SAT

Paulmyer-Lacroix, 2002 [21]

n: 30

N/D

18 (60)

33.8 ± 5.3

N/D

N/D

BMI < 25 kg/m2: 1.6 (HA)

Female: 27 (90)

BMI ≥ 30 kg/m2: 4.0 (HA)a

Age: 37.8 ± 11.2

 

Ethnicity: N/D

 

Tomlinson, 2002 [26]

n: 32

0 (0)

11 (34.4)

28.1 ± 0.7

N/D

BMI < 30 kg/m2: 15.5 ± 0.3 (n-fold)

BMI < 30 kg/m2: 15.5 ± 0.4 (n-fold)

Female: 32 (100)

Age: 43 (28 – 65)

BMI ≥ 30 kg/m2: 14.8 ± 0.5 (n-fold)

BMI ≥ 30 kg/m2: 15.1 ± 0.5 (n-fold)

Ethnicity: N/D

Wake, 2003 [27]

n: 32

0 (0)

N/D

25.9 ± 0.9

N/D

N/D

r = 0.63 with BMIc

Female: 16 (50.0)

Age: 55.5 ± 3.0

Ethnicity: Caucasian

Lindsay, 2003 [13]

n: 31

N/D

N/D

35.4 ± 7.4

N/D

N/D

r = 0.34 with BMIa

Female: 14 (45.2)

Age: 28.8 ± 7.7

Ethnicity: 12 Caucasian

    19 Pima Indian

Engeli, 2004 [16]

n: 70

0 (0)

14 (20)

29.0 ± 3.1

N/D

N/D

BMI < 25 kg/m2: 0.5 (AU)

Female: 70 (100)

BMI ≥ 25 kg/m2: 0.9 (AU)a

 

Age: 57 ± 4

      
 

Ethnicity: Caucasian

      

Goedecke, 2006 [11]

n: 26

0 (0)

N/D

27.2 ± 0.9

N/D

r = 0.35 with VAT volume

r = 0.57 with VAT volumea

Female: 26 (100)

Age: 41 ± 2.0

Ethnicity: 11 Caucasian

    8 Mixed race

    7 Black

Desbriere, 2006 [15]

n: 22

0 (0)

12 (54.5)

30.2 ± 3.8

N/D

BMI < 25 kg/m2: 0.5 (AU)

BMI < 25 kg/m2: 0.5 (AU)

Female: 22 (100)

BMI ≥ 30 kg/m2: 2.2 (AU)a

BMI ≥ 30 kg/m2: 3.6 (AU)a

 

Age: 36.2 ± 7.5

      
 

Ethnicity: N/D

      

Mariniello, 2006 [19]

n: 24

N/D

8 (33.3)

34 ± 3.4

N/D

BMI < 30 kg/m2: 1 (n-fold)

N/D

Female: 17 (70.8)

BMI ≥ 30 kg/m2: 13 (n-fold)b

 

Age: 42 ± 10

      
 

Ethnicity: N/D

      

Alberti, 2007 [6]

n: 62

12 (19.4)

62 (100.0)

37.4 ± 5.1

25 (40.3)

BMI ≥ 30 kg/m2: 2.1 ± 0.9 (AU)

BMI ≥ 30 kg/m2: 1.4 ± 0.8 (AU)

Female: 52 (83.9)

Age: 44.4 ± 11.1

Ethnicity: N/D

 

Makkonen, 2007 [18]

n: 20

0 (0)

10 (50)

28.7 ± 1.4

N/D

N/D

BMI < 25 kg/m2: 0.3 ± 0.1 (n-fold)

Female: 20 (100)

BMI ≥ 25 kg/m2: 0.6 ± 0.1 (n-fold)a

 

Age: 36.5 ± 3.5

      
 

Ethnicity: Caucasian

      

Michailidou, 2007 [20]

n: 21

N/D

N/D

32.7 ± 1.5

N/D

r = 0.57 with BMIc

r = 0.58 with BMIa

Female: 21 (100)

Age: 35 ± 1

Ethnicity: Caucasian

Paulsen, 2007 [22]

n: 40

0 (0)

20 (50)

34.7 ± 3.8

0 (0)

BMI < 30 kg/m2: 0.01 (n-fold)

BMI < 30 kg/m2: 0.01 (n-fold)

Female: 20 (50)

BMI ≥ 30 kg/m2: 0.04 (n-fold)a

BMI ≥ 30 kg/m2: 0.05 (n-fold)a

 

Age: 41.3 ± 9.8

      
 

Ethnicity: N/D

      

Baudrand, 2010 [9]

n = 49

11 (22.4)

49 (100)

42 ± 6.1

31 (63.3)

N/D

N/D

Female: 35 (71)

Age: 42.2 ± 10.1

Ethnicity: N/D

Muñoz, 2009 [8]

n: 32

6 (18.8)

32 (100.0)

36.7 ± 3.8

16 (50.0)

BMI ≥ 30 kg/m2: 7.8 (4.7 – 11.8) (AU)

BMI ≥ 30 kg/m2: 11.4 (6.2 – 19.8) (AU)

Female: 21 (65.6)

Age: 40.2 ± 12.3

Ethnicity: N/D

Simonyte, 2009 [24]

n: 27

3 (9.7)

27 (100)

44.6 ± 4.5

N/D

BMI ≥ 30 kg/m2: 11.2 ± 4.9 (AU)

BMI ≥ 30 kg/m2: 14.1 ± 6.4 (AU)

Female: 27 (100)

Age: 41 ± 8.5

Ethnicity: Caucasian

Zha, 2009 [28]

n: 35

0 (0)

15 (50)

25.5 ± 1.5

N/D

BMI < 25 kg/m2: 1.0 (AU)

BMI < 25 kg/m2: 1.2 (AU)

Female: 17 (49)

BMI ≥ 25 kg/m2: 1.5 (AU)c

BMI ≥ 25 kg/m2: 1.5 (AU)c

Age: 49.5 ± 12.5

  

Ethnicity: Chinese

  

Svendsen, 2009 [25]

n: 24

N/D

16 (66.7)

30.0 ± 2.7

N/D

N/D

BMI < 25 kg/m2: 0.09 (0.03–0.60) (AU)

Female: 24 (100)

BMI ≥ 25 kg/m2: 0.25 (0.09–0.84) (AU)a

Age: 30.7 ± 4.7

 

Ethnicity: N/D

 

Simonyte, 2010 [23]

n: 17

N/D

17 (100)

44.4 ± 4.4

N/D

N/D

r = 0.53 with WCa

Female: 17 (100)

Age: N/D

Ethnicity: N/D

Baudrand, 2011 [10]

n = 41

6 (14.6)

41 (100)

36.5 (36.5 – 47.0)

N/D

N/D

N/D

Female: 29 (70)

Age: 41.0 (34.0 – 47.5)

Ethnicity: N/D

Michalaki, 2012 [7]

n = 27

2 (7.4)

19 (70.4)

46.1 ± 6.6

11 (40.7)

BMI < 25 kg/m2: 27.8 ± 16 (AU)

BMI < 25 kg/m2: N/D

BMI ≥ 30 kg/m2: 81.6. ± 46.8 (AU)a

BMI ≥ 30 kg/m2: 115.7. ± 69.8 (AU)

 

Female: 27 (100)

      
 

Age: 37.3 ± 9.7

      
 

Ethnicity: N/D

      

Leyvraz, 2012 [17]

n = 35

N/D

30 (85.7)

41.3 ± 4.6

N/D

BMI < 30 kg/m2: 1.0 (0.6 – 1.4) (AU)

BMI < 30 kg/m2: 1.0 (0.8 – 1.2) (AU)

Female: 35 (100)

BMI ≥ 30 kg/m2: 2.9. (2.6 – 3.2) (AU)c

BMI ≥ 30 kg/m2: 2.2 (2.1 – 2.3) (AU)c

Age: 39.0 ± 9.0

  

Ethnicity: Caucasian

  
  1. Data expressed as absolute and relative frequencies, median (interquartile range), or mean ± standard deviation as appropriate. T2DM: type 2 diabetes mellitus; BMI: body mass index; MetS: metabolic syndrome; VAT: visceral adipose tissue; SAT: subcutaneous adipose tissue; HA: hybridized area/field; AU: arbitrary units; WC: waist circumference. aP < 0.05. bP < 0.001. cP < 0.01. r = Pearson’s correlation coefficient. N/D: not described; NS: non-significant.
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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