Association of HSD11B1 polymorphic variants and adipose tissue gene expression with metabolic syndrome, obesity and type 2 diabetes mellitus: a systematic review

Table 2 Relationship between HSD11B1 gene expression in abdominal adipose tissue and hyperglycemia: studies and subjects’ characteristics

Author, year	Subjects’ characteristics	T2DM	Obesity	BMI (kg/m ² )	MetS	Expression in VAT	Expression in SAT
Lindsay, 2003 [13]	n: 31	N/D	N/D	35.4 ± 7.4	N/D	N/D	r = 0.46, P < 0.05 with HOMA-IR
	Female: 14 (45.2)
	Age: 28.8 ± 7.7
	Ethnicity: 12 Caucasian
	19 Pima Indian
Goedecke, 2006 [11]	n: 26	0 (0)	N/D	27.2 ± 0.9	N/D	r = −0.13, P = NS with fasting glucose	r = 0.40, P < 0.016 with fasting glucose
	Female: 26 (100)
	Age: 41 ± 2.0
	Ethnicity: 11 Caucasian
	8 Mixed race
	7 Black
Alberti, 2007 [8]	n: 62	12 (19.4)	62 (100.0)	37.4 ± 5.1	25 (40.3)	N/D	r = 0.460, P < 0.0001 with fasting glucose
	Female: 52 (83.9)
	Age: 44.4 ± 11.1
	Ethnicity: N/D
Tomlinson, 2008 [14]	n = 101	7 (6.9)	101 (100)	34.4 ± 4.3	N/D	N/D	r = 0.44, P < 0.005 with glucose AUC
	Female: 66 (65.3)
	Age: 48.0 ± 7.0
	Ethnicity: N/D
Muñoz, 2009 [8]	n: 32	6 (18.8)	32 (100.0)	36.7 ± 3.8	16 (50.0)	r = −0.19, P = NS with fasting glucose	r = 0.15, P = NS with fasting glucose
	Female: 21 (65.6)
	Age: 40.2 ± 12.3
	Ethnicity: N/D
Baudrand, 2010 [9]	n = 49	11 (22.4)	49 (100)	42 ± 6.1	31 (63.3)	r = 0.48, P = 0.005 with fasting insulin	N/D
	Female: 35 (71)					r = 0.48, P = 0.005 with fasting insulin
	Age: 42.2 ± 10.1
	Ethnicity: N/D
Baudrand, 2011 [11]	n = 41	6 (14.6)	41 (100)	36.5 (36.5 – 47.0)	N/D	r = 0.37, P = 0.025 with fasting glucose	N/D
	Female: 29 (70)
	Age: 41.0 (34.0 – 47.5)
	Ethnicity: N/D
Gyllenhammer, 2014 [12]	n = 36	N/D	36 (100)	35.2 ± 0.6	N/D	N/D	r = −0.574, P = 0.140 with disposition index
	Female: 23 (63.9)
	Age: 21.5 ± 0.4
	Ethnicity: 16 African-Americans
	20 Hispanics

Data expressed as absolute and relative frequencies or mean ± standard deviation or median (p25 – p75) as appropriate. T2DM: type 2 diabetes mellitus; BMI: body mass index; MetS: metabolic syndrome; VAT: visceral adipose tissue; SAT: subcutaneous adipose tissue; N/D: not described; AUC: area under the curve in oral glucose tolerance test; NS: non-significant.

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