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Table 2 Average rhythmic parameters in insulin, melatonin and insulin plus melatonin early-treated diabetic animals

From: Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats

  Insulin treated group
  Control 1st Insulin Diabetic 2nd Insulin
MESOR 37.55 ± 0.01850 37.59 ± 0.02640 37.18 ± 0.06034***bbb 37.41 ± 0.05469aab
Amplitude 0.2814 ± 0.01969 0.3546 ± 0.0248 0.3915 ± 0.042 0.4329 ± 0.0908*
Acrophase 15.46 ± 0.4256 14.31 ± 0.2471 15.18 ± 0.6522 14.27 ± 0.4303
  Melatonin supplemented group
  Control 1st Melatonin Diabetic 2nd Melatonin
MESOR 38.15 ± 0.01875 37.84 ± 0.02414*** 37.57 ± 0.05185***bbb 37.84 ± 0.03808***aaa
Amplitude 0.3157 ± 0.02467 0.3460 ± 0.02156 0.3473 ± 0.02697 0.3477 ± 0.02822
Acrophase 16.57 ± 0.5227 16.66 ± 0.6569 14.60 ± 1.400 16.57 ± 0.2733
  Insulin + Melatonin treated group
  Control 1st Insulin + Melatonin Diabetic 2nd Insulin + Melatonin
MESOR 37.55 ± 0.01672 37.58 ± 0.01696* 37.29 ± 0.08757bb 37.44 ± 0.04681
Amplitude 0.2543 ± 0.02553 0.3740 ± 0.02801 0.4218 ± 0.03670* 0.4127 ± 0.03099*
Acrophase 18.08 ± 0.4162 14.89 ± 0.1850*** 14.63 ± 0.7259*** 15.06 ± 0.4708**
  1. ONE-Way ANOVA with p < 0.05 for the treatment factor followed by Bonferroni post-test. ***p < 0.001, **p < 0.01, *p < 0.05 vs Control, aaa p < 0.001,aa p < 0.01 vs Diabetic, bbb p < 0.001, bb p < 0.01,b p < 0.05 vs 1st Insulin, ***p < 0.001 vs Control, aaa p < 0.001 vs Diabetic, bbb p < 0.001 vs 1st Melatonin, ***p < 0.001, **p < 0.01, *p < 0.05 vs Control, bb p < 0.01 vs 1st Insulin + Melatonin. Mean ± SEMn.