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Table 2 Average rhythmic parameters in insulin, melatonin and insulin plus melatonin early-treated diabetic animals

From: Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats

 

Insulin treated group

 

Control

1st Insulin

Diabetic

2nd Insulin

MESOR

37.55 ± 0.01850

37.59 ± 0.02640

37.18 ± 0.06034***bbb

37.41 ± 0.05469aab

Amplitude

0.2814 ± 0.01969

0.3546 ± 0.0248

0.3915 ± 0.042

0.4329 ± 0.0908*

Acrophase

15.46 ± 0.4256

14.31 ± 0.2471

15.18 ± 0.6522

14.27 ± 0.4303

 

Melatonin supplemented group

 

Control

1st Melatonin

Diabetic

2nd Melatonin

MESOR

38.15 ± 0.01875

37.84 ± 0.02414***

37.57 ± 0.05185***bbb

37.84 ± 0.03808***aaa

Amplitude

0.3157 ± 0.02467

0.3460 ± 0.02156

0.3473 ± 0.02697

0.3477 ± 0.02822

Acrophase

16.57 ± 0.5227

16.66 ± 0.6569

14.60 ± 1.400

16.57 ± 0.2733

 

Insulin + Melatonin treated group

 

Control

1st Insulin + Melatonin

Diabetic

2nd Insulin + Melatonin

MESOR

37.55 ± 0.01672

37.58 ± 0.01696*

37.29 ± 0.08757bb

37.44 ± 0.04681

Amplitude

0.2543 ± 0.02553

0.3740 ± 0.02801

0.4218 ± 0.03670*

0.4127 ± 0.03099*

Acrophase

18.08 ± 0.4162

14.89 ± 0.1850***

14.63 ± 0.7259***

15.06 ± 0.4708**

  1. ONE-Way ANOVA with p < 0.05 for the treatment factor followed by Bonferroni post-test. ***p < 0.001, **p < 0.01, *p < 0.05 vs Control, aaa p < 0.001,aa p < 0.01 vs Diabetic, bbb p < 0.001, bb p < 0.01,b p < 0.05 vs 1st Insulin, ***p < 0.001 vs Control, aaa p < 0.001 vs Diabetic, bbb p < 0.001 vs 1st Melatonin, ***p < 0.001, **p < 0.01, *p < 0.05 vs Control, bb p < 0.01 vs 1st Insulin + Melatonin. Mean ± SEMn.