Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats

Table 1 Average rhythmic parameters in insulin, melatonin and insulin plus melatonin late-treated diabetic animals

	Insulin treated group
	Control	Diabetic	Insulin
MESOR	37.59 ± 0.01487	36.48 ± 0.07885^***	37.22 ± 0.07453^aaa
Amplitude	0.2300 ± 0.02289	0.5556 ± 0.03913^***	0.5521 ± 0.05900^**
Acrophase	13.45 ± 0.9341	10.58 ± 0.4889^*	9.762 ± 0.6649^**
	Melatonin supplemented group
	Control	Diabetic	Melatonin
MESOR	37.47 ± 0.01503	36.75 ± 0.07445^***	36.48 ± 0.07706^***
Amplitude	0.2357 ± 0.01950	0.555 ± 0.06827^*	0.5917 ± 0.06674^*
Acrophase	14.59 ± 0.4758	11.04 ± 0.7539	11.59 ± 0.9328
	Insulin + melatonin treated group
	Control	Diabetic	Insulin + Melatonin
MESOR	37.62 ± 0.01857	36.96 ± 0.06499^***	37.38 ± 0.05622^aaa
Amplitude	0.3057 ± 0.02103	0.5291 ± 0.05421^*	0.4533 ± 0.03055
Acrophase	14.65 ± 0.4103	13.65 ± 0.4664	13.90 ± 0.2138

ONE-Way ANOVA with p < 0.05 for the treatment factor followed by Bonferroni post-test. ***P < 0.001, **P < 0.01, *P < 0.05 vs Control, ^aaa P < 0.001 vs Diabetic, ***p < 0.001, *p < 0.05 vs Control, ***p < 0.001, *p < 0.05 vs Control, ^aaa p < 0.001 vs Diabetic. Mean ± SEM.

ISSN: 1758-5996