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Table 1 Average rhythmic parameters in insulin, melatonin and insulin plus melatonin late-treated diabetic animals

From: Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats

  Insulin treated group
  Control Diabetic Insulin
MESOR 37.59 ± 0.01487 36.48 ± 0.07885*** 37.22 ± 0.07453aaa
Amplitude 0.2300 ± 0.02289 0.5556 ± 0.03913*** 0.5521 ± 0.05900**
Acrophase 13.45 ± 0.9341 10.58 ± 0.4889* 9.762 ± 0.6649**
  Melatonin supplemented group
  Control Diabetic Melatonin
MESOR 37.47 ± 0.01503 36.75 ± 0.07445*** 36.48 ± 0.07706***
Amplitude 0.2357 ± 0.01950 0.555 ± 0.06827* 0.5917 ± 0.06674*
Acrophase 14.59 ± 0.4758 11.04 ± 0.7539 11.59 ± 0.9328
  Insulin + melatonin treated group
  Control Diabetic Insulin + Melatonin
MESOR 37.62 ± 0.01857 36.96 ± 0.06499*** 37.38 ± 0.05622aaa
Amplitude 0.3057 ± 0.02103 0.5291 ± 0.05421* 0.4533 ± 0.03055
Acrophase 14.65 ± 0.4103 13.65 ± 0.4664 13.90 ± 0.2138
  1. ONE-Way ANOVA with p < 0.05 for the treatment factor followed by Bonferroni post-test. ***P < 0.001, **P < 0.01, *P < 0.05 vs Control, aaa P < 0.001 vs Diabetic, ***p < 0.001, *p < 0.05 vs Control, ***p < 0.001, *p < 0.05 vs Control, aaa p < 0.001 vs Diabetic. Mean ± SEM.