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Table 5 Relationship of IL6 -174G > C with anthropometric, metabolic and inflammatory variables

From: ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Variable

Genotypes

  
 

GG (112)

GC + CC (137)

P-value

Body mass index, kg/m2

31.2 ± 6.1

30.7 ± 6.3

0.528

Waist circumference, cm

96.4 ± 16.1

92.6 ± 15.7

0.067

Waist- hip ratio

0.87 ± 0.10

0.85 ± 0.10

0.164

Body fat, %

35.5 ± 6.0

36.4 ± 6.2

0.246

BMR, kcal

1644 ± 373

1543 ± 298

0.057

Leptin, ng/mL

21.8 ± 18.6

18.6 ± 15.6

0.394

sLEPR, ng/mL

22.4 ± 23.3

19.2 ± 18.8

0.615

Adiponectin, μg/mL

24.0 ± 24.0

24.5 ± 25.9

0.755

Glucose, mg/dL

103 ± 31

102 ± 21

0.072

HbA1c, %

6.0 ± 1.4

5.9 ± 1.1

0.876

Insulin, mU/L

17.7 ± 13.6

14.3 ± 9.8

0.237

HOMA-β

57.0 ± 40.3

47.4 ± 34.4

0.148

HOMA-IR

4.9 ± 5.3

3.7 ± 2.7

0.379

Total cholesterol, mg/dL

205 ± 42

204 ± 36

0.755

HDL ccholesterol, mg/dL

56 ± 19

54 ± 12

0.823

LDL cholesterol, mg/dL

122 ± 34

127 ± 31

0.241

VLDL cholesterol, mg/dL

26 ± 19

25 ± 13

0.759

Triglycerides, mg/dL

132 ± 94

124 ± 64

0.759

Apolipoprotein AI, mg/dL

152 ± 35

148 ± 34

0.753

Apolipoprotein B, mg/dL

101 ± 27

100 ± 34

0.462

Fibrinogen, mg/dL

355 (317–407)

365 (319–420)

0.325

PAI-1, pg/mL

82.7 (57.5-133.5)

75.2 (56.3-145.9)

0.991

IL-6, pg/mL

0.48 (0.08-0.64)

0.28 (0.08-0.96)

0.288

IL-1β, pg/dL

15.0 (4.0-45.0)

13.5 (4.0-32.0)

0.033

hsCRP, mg/L

0.57 (0.13-3.2)

0.52 (0.10-2.94)

0.808

TNFα, pg/mL

2.62 (0.41-4.92)

2.29 (0.49-5.18)

0.666

  1. Number of individuals is in parenthesis. Results are shown as mean ± SD or median (interquartile range) and compared by Mann–Whitney Rank sum test. BMR: basal metabolic rate; CAD: coronary artery disease; HDL: high-density lipoprotein; LDL: low-density lipoprotein; hsCRP: high sensitive C reactive protein; IL-6: interleukin 6; IL-1β: interleukin 1beta; PAI-1: plasminogen activator inhibitor-1; sLEPR: soluble leptin receptor; TNFα: tumor necrosis factor alpha; VLDL: very low-density lipoprotein.