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Table 3 Influence of clinical, biochemical and genetic variables on the risk for overweight and obesity: Univariate logistic regression analysis

From: ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Independent variables Risk for overweight   Risk for Obesity  
  OR 95% CI P-value OR 95% CI P-value
Clinical and anthropometric variables       
Age, years 1.02 0.97 – 1.06 0.453 1.03 0.99 – 1.07 0.145
Gender [ref: male] 0.37 0.11 – 1.25 0.110 0.25 0.08 – 0.73 0.011
Ethnics [ref: white] 0.64 0.26 – 1.55 0.318 0.67 0.31 – 1.43 0.297
Menopause 1.13 0.50 – 2.52 0.774 0.54 0.27 – 1.08 0.081
Hypertension 2.48 0.92 – 6.72 0.074 5.32 2.25 – 12.60 <0.001
T2DM 1.42 0.64 – 3.15 0.390 4.40 2.23 – 8.69 <0.001
Dyslipidemia 3.30 1.48 – 7.38 0.004 5.02 2.53 – 9.97 <0.001
Family history of CAD       
Tobacco smoking 1.09 0.40 – 2.94 0.872 0.71 0.30 – 1.69 0.437
Alcohol consumption 1.96 0.17 – 22.32 0.587 1.80 0.21 -15.77 0.596
Physical exercise practice 0.93 0.43 – 2.00 0.845 0.41 0.21 – 0.79 0.008
Waist circumference, cm 1.21 1.12 – 1.30 <0.001 1.42 1.30 – 1.55 <0.001
Body fat, % 1.13 1.04 – 1.23 0.004 1.34 1.23 – 1.46 <0.001
Biochemical parameters       
Leptin, ng/mL 1.02 0.98 – 1.06 0.434 1.05 1.01 – 1.08 0.006
sLEPR, ng/mL 0.99 0.90 – 1.01 0.397 0.99 0.97 – 1.01 0.421
Adiponectin, μg/mL 0.99 0.97–- 1.01 0.155 1.00 0.99 – 1.02 0.555
Fibrinogen, mg/dL 1.01 1.00 – 1.01 0.037 1.01 1.00 – 1.01 <0.001
PAI-1, pg/mL 1.03 0.98 – 1.08 0.204 1.04 1.00 – 1.08 0.057
IL-6, pg/mL 1.23 0.91 – 1.67 0.183 1.24 0.92 – 1.66 0.154
IL-1β, pg/dL 1.08 1.01 – 1.16 0.029 1.14 1.06 – 1.22 <0.001
hsCRP, mg/L 1.24 0.87 – 1.76 0.232 1.75 1.28 – 2.3 <0.001
TNFα, pg/mL 1.18 0.96 – 1.45 0.123 1.35 1.13 – 1.62 0.001
Polymorphisms       
ADIPOQ 45 T > G (ref TT) 1.03 0.46 - 2.32 0.946 1.06 0.54 - 2.09 0.858
IL6 -174G > C (ref GG) 1.50 0.68 - 3.30 0.317 0.95 0.50 - 1.81 0.884
  1. Results obtained from a univariate nominal regression analysis using the normoweight subjects as reference group. OR, odds ratio; CI, confidence interval. Polymorphisms were introduced as dummy variables for absence or presence of the rare allele.