|
Independent variables
|
Risk for overweight
| |
Risk for Obesity
| |
|---|
| |
OR
|
95% CI
|
P-value
|
OR
|
95% CI
|
P-value
|
|---|
|
Clinical and anthropometric variables
| | | | | | |
|
Age, years
|
1.02
|
0.97 – 1.06
|
0.453
|
1.03
|
0.99 – 1.07
|
0.145
|
|
Gender [ref: male]
|
0.37
|
0.11 – 1.25
|
0.110
|
0.25
|
0.08 – 0.73
|
0.011
|
|
Ethnics [ref: white]
|
0.64
|
0.26 – 1.55
|
0.318
|
0.67
|
0.31 – 1.43
|
0.297
|
|
Menopause
|
1.13
|
0.50 – 2.52
|
0.774
|
0.54
|
0.27 – 1.08
|
0.081
|
|
Hypertension
|
2.48
|
0.92 – 6.72
|
0.074
|
5.32
|
2.25 – 12.60
|
<0.001
|
|
T2DM
|
1.42
|
0.64 – 3.15
|
0.390
|
4.40
|
2.23 – 8.69
|
<0.001
|
|
Dyslipidemia
|
3.30
|
1.48 – 7.38
|
0.004
|
5.02
|
2.53 – 9.97
|
<0.001
|
|
Family history of CAD
| | | | | | |
|
Tobacco smoking
|
1.09
|
0.40 – 2.94
|
0.872
|
0.71
|
0.30 – 1.69
|
0.437
|
|
Alcohol consumption
|
1.96
|
0.17 – 22.32
|
0.587
|
1.80
|
0.21 -15.77
|
0.596
|
|
Physical exercise practice
|
0.93
|
0.43 – 2.00
|
0.845
|
0.41
|
0.21 – 0.79
|
0.008
|
|
Waist circumference, cm
|
1.21
|
1.12 – 1.30
|
<0.001
|
1.42
|
1.30 – 1.55
|
<0.001
|
|
Body fat, %
|
1.13
|
1.04 – 1.23
|
0.004
|
1.34
|
1.23 – 1.46
|
<0.001
|
|
Biochemical parameters
| | | | | | |
|
Leptin, ng/mL
|
1.02
|
0.98 – 1.06
|
0.434
|
1.05
|
1.01 – 1.08
|
0.006
|
|
sLEPR, ng/mL
|
0.99
|
0.90 – 1.01
|
0.397
|
0.99
|
0.97 – 1.01
|
0.421
|
|
Adiponectin, μg/mL
|
0.99
|
0.97–- 1.01
|
0.155
|
1.00
|
0.99 – 1.02
|
0.555
|
|
Fibrinogen, mg/dL
|
1.01
|
1.00 – 1.01
|
0.037
|
1.01
|
1.00 – 1.01
|
<0.001
|
|
PAI-1, pg/mL
|
1.03
|
0.98 – 1.08
|
0.204
|
1.04
|
1.00 – 1.08
|
0.057
|
|
IL-6, pg/mL
|
1.23
|
0.91 – 1.67
|
0.183
|
1.24
|
0.92 – 1.66
|
0.154
|
|
IL-1β, pg/dL
|
1.08
|
1.01 – 1.16
|
0.029
|
1.14
|
1.06 – 1.22
|
<0.001
|
|
hsCRP, mg/L
|
1.24
|
0.87 – 1.76
|
0.232
|
1.75
|
1.28 – 2.3
|
<0.001
|
|
TNFα, pg/mL
|
1.18
|
0.96 – 1.45
|
0.123
|
1.35
|
1.13 – 1.62
|
0.001
|
|
Polymorphisms
| | | | | | |
|
ADIPOQ 45 T > G (ref TT)
|
1.03
|
0.46 - 2.32
|
0.946
|
1.06
|
0.54 - 2.09
|
0.858
|
|
IL6 -174G > C (ref GG)
|
1.50
|
0.68 - 3.30
|
0.317
|
0.95
|
0.50 - 1.81
|
0.884
|
- Results obtained from a univariate nominal regression analysis using the normoweight subjects as reference group. OR, odds ratio; CI, confidence interval. Polymorphisms were introduced as dummy variables for absence or presence of the rare allele.
