ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Raquel de Oliveira; Tamiris Invencioni Moraes; Alvaro Cerda; Mario Hiroyuki Hirata; Cristina Moreno Fajardo; Marcela Correia Sousa; Egidio Lima Dorea; Márcia Martins Silveira Bernik; Rosario Dominguez Crespo Hirata

doi:10.1186/s13098-015-0027-2

Diabetology & Metabolic Syndrome

Table 3 Influence of clinical, biochemical and genetic variables on the risk for overweight and obesity: Univariate logistic regression analysis

From: ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Independent variables	*Risk for overweight*			*Risk for Obesity*
	OR	95% CI	*P-value*	OR	95% CI	*P-value*
Clinical and anthropometric variables
Age, years	1.02	0.97 – 1.06	0.453	1.03	0.99 – 1.07	0.145
Gender [ref: male]	0.37	0.11 – 1.25	0.110	0.25	0.08 – 0.73	*0.011*
Ethnics [ref: white]	0.64	0.26 – 1.55	0.318	0.67	0.31 – 1.43	0.297
Menopause	1.13	0.50 – 2.52	0.774	0.54	0.27 – 1.08	0.081
Hypertension	2.48	0.92 – 6.72	0.074	5.32	2.25 – 12.60	*<0.001*
T2DM	1.42	0.64 – 3.15	0.390	4.40	2.23 – 8.69	*<0.001*
Dyslipidemia	3.30	1.48 – 7.38	*0.004*	5.02	2.53 – 9.97	*<0.001*
Family history of CAD
Tobacco smoking	1.09	0.40 – 2.94	0.872	0.71	0.30 – 1.69	0.437
Alcohol consumption	1.96	0.17 – 22.32	0.587	1.80	0.21 -15.77	0.596
Physical exercise practice	0.93	0.43 – 2.00	0.845	0.41	0.21 – 0.79	*0.008*
Waist circumference, cm	1.21	1.12 – 1.30	*<0.001*	1.42	1.30 – 1.55	*<0.001*
Body fat, %	1.13	1.04 – 1.23	*0.004*	1.34	1.23 – 1.46	*<0.001*
Biochemical parameters
Leptin, ng/mL	1.02	0.98 – 1.06	0.434	1.05	1.01 – 1.08	*0.006*
sLEPR, ng/mL	0.99	0.90 – 1.01	0.397	0.99	0.97 – 1.01	0.421
Adiponectin, μg/mL	0.99	0.97–- 1.01	0.155	1.00	0.99 – 1.02	0.555
Fibrinogen, mg/dL	1.01	1.00 – 1.01	*0.037*	1.01	1.00 – 1.01	*<0.001*
PAI-1, pg/mL	1.03	0.98 – 1.08	0.204	1.04	1.00 – 1.08	0.057
IL-6, pg/mL	1.23	0.91 – 1.67	0.183	1.24	0.92 – 1.66	0.154
IL-1β, pg/dL	1.08	1.01 – 1.16	*0.029*	1.14	1.06 – 1.22	*<0.001*
hsCRP, mg/L	1.24	0.87 – 1.76	0.232	1.75	1.28 – 2.3	*<0.001*
TNFα, pg/mL	1.18	0.96 – 1.45	0.123	1.35	1.13 – 1.62	*0.001*
Polymorphisms
ADIPOQ 45 T > G (ref TT)	1.03	0.46 - 2.32	0.946	1.06	0.54 - 2.09	0.858
IL6 -174G > C (ref GG)	1.50	0.68 - 3.30	0.317	0.95	0.50 - 1.81	0.884

Results obtained from a univariate nominal regression analysis using the normoweight subjects as reference group. OR, odds ratio; CI, confidence interval. Polymorphisms were introduced as dummy variables for absence or presence of the rare allele.

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