| |
Aspirin non-user
|
Low-dose aspirin user
| | |
|---|
| |
Event (N)
|
Person-years
|
Crude incidence rate (/1,000 person-years)
|
Event (N)
|
Person-years
|
Crude incidence rate (/1,000 person-years)
|
Crude Hazard Ratio (95% CI)
|
Adjusted Hazard Ratio
*
(95% CI)
|
|---|
|
Whole matched cohort
|
84
|
48,553
|
1.7
|
139
|
44,527
|
3.1
|
1.85 (1.41-2.44)
|
1.97 (1.51-2.62)
|
|
Gender
|
Male
|
42
|
27,476
|
1.5
|
78
|
25,182
|
3.1
|
3.01 (2.12-4.28)
|
3.25 (2.28-4.63)
|
| |
Female
|
42
|
21,077
|
2.0
|
61
|
19,345
|
3.2
|
1.65 (1.65-2.45)
|
1.72 (1.16-2.57)
|
|
Age
|
40-69
|
48
|
39,633
|
1.2
|
85
|
37,019
|
2.3
|
1.98 (1.98-2.62)
|
2.12 (1.48-3.03)
|
| |
70-99
|
36
|
8,921
|
4.0
|
54
|
7,508
|
7.2
|
1.79 (1.79-2.74)
|
1.89 (1.23-2.91)
|
|
Type of diabetes
|
Type 1 only
|
8
|
3,064
|
2.6
|
8
|
2,282
|
3.5
|
1.32 (0.50-3.52)
|
1.38 (0.50-3.77)
|
| |
Type 2 and others
|
76
|
45,489
|
1.7
|
131
|
42,245
|
3.1
|
1.91 (1.44-2.54)
|
2.05 (1.54-2.74)
|
|
Diabetes with essential hypertension
|
Yes
|
48
|
24,669
|
1.9
|
82
|
21,272
|
3.9
|
2.03 (1.42-2.91)
|
2.14 (1.50-3.07)
|
|
No
|
36
|
23,885
|
1.5
|
57
|
23,225
|
2.5
|
1.67 (1.09-2.54)
|
1.78 (1.16-2.73)
|
|
Diabetes with dyslipidemia
|
Yes
|
24
|
13,444
|
1.8
|
27
|
11,240
|
2.4
|
1.34 (0.78-2.34)
|
1.60 (0.92-2.82)
|
|
No
|
60
|
35,109
|
1.7
|
112
|
33,287
|
3.4
|
2.04 (1.49-2.80)
|
2.13 (1.55-2.93)
|
- CI: confidence interval.
-
*Adjusted Hazard Ratio calculated using Cox proportional hazard model adjusting for insurance type, anti-diabetic medications at baseline, use of statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta blockers, calcium channel blockers and thiazide diuretics during follow-up.
