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Table 3 Sensitivity analysis for incidence rates and risk of ischemic stroke associated with use of low-dose aspirin among patients with diabetes who completed more than 1 year follow-up periods after index date
| Aspirin non-user | Low-dose aspirin user | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Event (N) | Person-years | Crude incidence rate (/1,000 person-years) | Event (N) | Person-years | Crude incidence rate (/1,000 person-years) | Crude Hazard Ratio (95% CI) | Adjusted Hazard Ratio * (95% CI) | ||
| Whole matched cohort | 84 | 48,553 | 1.7 | 139 | 44,527 | 3.1 | 1.85 (1.41-2.44) | 1.97 (1.51-2.62) | |
| Gender | Male | 42 | 27,476 | 1.5 | 78 | 25,182 | 3.1 | 3.01 (2.12-4.28) | 3.25 (2.28-4.63) |
| Female | 42 | 21,077 | 2.0 | 61 | 19,345 | 3.2 | 1.65 (1.65-2.45) | 1.72 (1.16-2.57) | |
| Age | 40-69 | 48 | 39,633 | 1.2 | 85 | 37,019 | 2.3 | 1.98 (1.98-2.62) | 2.12 (1.48-3.03) |
| 70-99 | 36 | 8,921 | 4.0 | 54 | 7,508 | 7.2 | 1.79 (1.79-2.74) | 1.89 (1.23-2.91) | |
| Type of diabetes | Type 1 only | 8 | 3,064 | 2.6 | 8 | 2,282 | 3.5 | 1.32 (0.50-3.52) | 1.38 (0.50-3.77) |
| Type 2 and others | 76 | 45,489 | 1.7 | 131 | 42,245 | 3.1 | 1.91 (1.44-2.54) | 2.05 (1.54-2.74) | |
| Diabetes with essential hypertension | Yes | 48 | 24,669 | 1.9 | 82 | 21,272 | 3.9 | 2.03 (1.42-2.91) | 2.14 (1.50-3.07) |
| No | 36 | 23,885 | 1.5 | 57 | 23,225 | 2.5 | 1.67 (1.09-2.54) | 1.78 (1.16-2.73) | |
| Diabetes with dyslipidemia | Yes | 24 | 13,444 | 1.8 | 27 | 11,240 | 2.4 | 1.34 (0.78-2.34) | 1.60 (0.92-2.82) |
| No | 60 | 35,109 | 1.7 | 112 | 33,287 | 3.4 | 2.04 (1.49-2.80) | 2.13 (1.55-2.93) | |
