Skip to main content

Table 1 Characteristics of animals

From: Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

 

Ctrl

DM

DM + ramipril

RSA

AGE-RSA

Number

15

15

16

9

10

Plasma glucose (mmol/L)

6.9 ± 095

33.2 ± 2.7*

33.1 ± 3.5*

7.9 ± 1.0

7.5 ± 0.5

%HbA1c (%)

5.5 ± 0.7

18.3 ± 2.6*

19.3 ± 2.7*

4.1 ± 1.5

3.9 ± 0.8

Systolic BP (mmHg)

114 ± 9

134 ± 13*

122 ± 8#

121 ± 4

118 ± 7

KW/BW ratio

5.3 ± 0.6

10.9 ± 1.5*

11.3 ± 1.1*

5.4 ± 0.3

5.4 ± 0.4

eGFR (ml/min)

6.7 ± 1.1

11.2 ± 1.4*

12.0 ± 1.7*

4.3 ± 1.0

4.4 ± 0.6

UAE (mg/24 h)

5.6 ± 4.3

53.9 ± 51.8*

13.0 ± 6.8$

1.0 ± 0.4

1.3 ± 0.5

  1. Data are mean ± SEM. *p < 0.001 vs Ctrl, #p < 0.05 vs Ctrl, $p < 0.001 vs DM.
  2. Abbreviation: Ctrl control, DM diabetes mellitus, RSA rat serum albumin, AGE-RSA advanced glycation end product-modified RSA, HbA1c glycated hemoglobin, BP blood pressure, KW/BW ratio kidney-to-body weight ratio, GFR glomerular filtration rate, UAE urinary albumin excretion.