CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models

Table 2 Specific target genes of nuclear receptors involved in glucose and fat metabolism

Organ	Heterodimer	Gene	Function	Ref
Liver	RXR/PPARα	ABCB4	Biliary phosphotidyl choline secretion	[32, 33]
		ApoAII	Constituent of HDL-C	[34]
		ACOX1	Peroxisomal fatty acid oxidation	[35]
	RXR/LXR	SREBP1c	Regulation of enzymes of fatty acid synthesis	[36]
		SCD1	Palmitic to palmitoleic and stearic to oleic acid	[37]
		FASN	De novo synthesis of fatty acids	[38]
		THRSP	Lipogenesis	[39]
		ABCG5/ABCG8	Biliary secretion of cholesterol and phytosterols	[40]
Adipose	PPARγ	SCD1	Palmitic to palmitoleic and stearic to oleic acid	[41]
	LXR	PPARγ	Adipogenesis	[42]
		SREBP1c	Regulation of enzymes of fatty acid synthesis	[42]
		SCD1	Palmitic to palmitoleic and stearic to oleic acid	[43]
Muscle	PPARδ	PDK4	Fatty acid oxidation	[44]
		UCP3	Fatty acid oxidation and oxidative stress	[45]

ISSN: 1758-5996