From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models
Nuclear receptors
CNX-013-B2
Bexarotene
EC50(nM)
RXRα
48
18
RXRβ
66
ND
RXRγ
68
RXRα: PPARα
159
RXRα: PPARδ
178
RXRα: PPARγ
196