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Table 1 Potency towards RXR homedimers and heterodimers

From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models

Nuclear receptors

CNX-013-B2

Bexarotene

 

EC50(nM)

RXRα

48

18

RXRβ

66

ND

RXRγ

68

ND

RXRα: PPARα

159

ND

RXRα: PPARδ

178

ND

RXRα: PPARγ

196

ND