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Figure 6 | Diabetology & Metabolic Syndrome

Figure 6

From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models

Figure 6

CNX-013-B2 inhibits Cdk5-mediated Phosphorylation of PPARγ at Ser-273 and also increases serum adiponectin levels. Inguinal (A) and mesenteric (B) adipose tissue from DIO study were analyzed with phospho-Ser 273 PPARγ antibodies, normalized to beta-Actin. C- Serum adiponectin levels in DIO mice. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with DIO control.

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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