Figure 4From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal modelsCNX-013-B2 reduces body weight and enhances non-shivering thermogenesis. A- Body weight in DIO mice, B-Absolute adipose depot weight, C- mesenteric adipocyte size, D- Body weight gain in ob/ob mice, E-.Cold temperature tolerance in DIO mice, F- SDH activity in gastrocnemius muscle of DIO mice, G and H-, UCPI expression levels in inguinal and brown adipocyte, I- H&E of adipocytes and J-UCP1 quantification in inguinal adipocytes. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with DIO control. (#) <0.05, (##), <0.01 and (###) <0.001 as compared to lean or ob/+.Back to article page