Figure 1From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal modelsCNX-013-B2 improves insulin sensitivity and glucose tolerance in C57BL6/j DIO mice on High Fat Diet. A- OGTT in DIO on week 10 of treatment. Circle-Lean control, Diamond-DIO control and Triangle-CNX-013-B2 (10 mpk, bid). B- Insulin levels during OGTT. B insert- Insulin AUC, C- Glucose AUC 0–180 min, D- Fed insulin, E-fasting (6 h) and F-HOMA-IR. G & H- p-AKT levels in muscle and mesenteric adipose. (I)- p-JNK levels in gastrocnemius muscle. (J)- p-JNK levels in liver. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s post hoc test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with DIO mice. (#) <0.05, (##), <0.01 and (###) <0.001 as compared to lean mice.Back to article page