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Figure 1 | Diabetology & Metabolic Syndrome

Figure 1

From: CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models

Figure 1

CNX-013-B2 improves insulin sensitivity and glucose tolerance in C57BL6/j DIO mice on High Fat Diet. A- OGTT in DIO on week 10 of treatment. Circle-Lean control, Diamond-DIO control and Triangle-CNX-013-B2 (10 mpk, bid). B- Insulin levels during OGTT. B insert- Insulin AUC, C- Glucose AUC 0–180 min, D- Fed insulin, E-fasting (6 h) and F-HOMA-IR. G & H- p-AKT levels in muscle and mesenteric adipose. (I)- p-JNK levels in gastrocnemius muscle. (J)- p-JNK levels in liver. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s post hoc test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with DIO mice. (#) <0.05, (##), <0.01 and (###) <0.001 as compared to lean mice.

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