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Table 3 Incidence and hazard ratio of nephropathy and mortality according to age and blood pressure control

From: Effects of glucose and blood pressure control on diabetic kidney disease in old patients with type 2 diabetes

  Time-weighted average of SBP (mm Hg)
<128 (1sttertile) 128-141 (2ndtertile) >141 (3rdtertile)
Aged 41–70 years (patient-years) 129 (938) 102 (712) 110 (764)
Clinical albuminuria    
 Events and rate (per 1000 patient-years) 12 (12.8) 17 (23.9) 33 (86.4)
 Adjusted hazard ratio 1 1.90 (0.91–3.98) 3.70 (1.91–7.17)
eGFR <30 mL/[min · 1.73 m2]    
 Events and rate (per 1000 patient-years) 5 (5.33) 9 (12.6) 11 (14.4)
 Adjusted hazard ratio 1 2.44 (0.81–7.29) 2.67 (1.03–7.67)
End-stage renal disease    
 Events and rate (per 1000 patient-years) 2 (2.13) 4 (5.62) 6 (7.85)
 Adjusted hazard ratio 1 2.71 (0.49–14.88) 3.56 (0.72–17.67)
All-cause mortality    
 Events and rate (per 1000 patient-years) 13 (13.9) 10 (14.0) 18 (23.6)
 Adjusted hazard ratio 1 1.04 (0.46–2.38) 1.77 (1.07–3.61)
Aged 71–85 years (patient-years) 120 (816) 136 (911) 124 (860)
Clinical albuminuria    
 Events and rate (per 1000 patient-years) 25 (30.6) 33 (36.2) 24 (27.9)
 Adjusted hazard ratio 1 1.09 (0.64–1.84) 1.03 (0.59–1.81)
eGFR <30 mL/[min · 1.73 m2]    
 Events and rate (per 1000 patient-years) 26 (31.9) 13 (14.3) 14 (16.3)
 Adjusted hazard ratio 1 0.45 (0.23–0.89) 0.62 (0.32–1.20)
End-stage renal disease    
 Events and rate (per 1000 patient-years) 10 (12.3) 2 (2.20) 3 (3.49)
 Adjusted hazard ratio 1 0.21 (0.04–0.95) 0.36 (0.10–1.32)
All-cause mortality    
 Events and rate (per 1000 patient-years) 43 (52.9) 33 (36.2) 29 (33.7)
 Adjusted hazard ratio 1 0.68 (0.43–1.09) 0.64 (0.40–1.03)
  1. Abbreviations: SBP Systolic blood pressure, eGFR Estimated glomerular filtration rate.
  2. Adjusted for sex, duration of diabetes, body mass index, smoking status, HbA1c, total cholesterol, HDL cholesterol, serum creatinine, urine albumin-to-creatinine ratio, and medications.