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Table 2 Incidence and hazard ratios of nephropathy and mortality according to age and glycemic control

From: Effects of glucose and blood pressure control on diabetic kidney disease in old patients with type 2 diabetes

  Time-weighted average of HbA1c
<7.3% (1st tertile) 7.3–8.5% (2nd tertile) >8.5% (3rd tertile)
Aged 41–70 years (patient-years) 102 (734) 113 (773) 126 (843)
Clinical albuminuria    
 Events and rate (per 1000 patient-years) 15 (20.4) 19 (24.6) 28 (33.2)
 Adjusted hazard ratio 1 1.07 (0.54–2.12) 1.64 (1.07–3.14)
eGFR <30 mL/[min · 1.73 m2]    
 Events and rate (per 1000 patient-years) 6 (8.17) 7 (9.06) 12 (14.2)
 Adjusted hazard ratio 1 1.15 (0.38–5.52) 1.99 (1.07–5.34)
End-stage renal disease    
 Events and rate (per 1000 patient-years) 1 (1.36) 6 (7.76) 5 (5.93)
 Adjusted hazard ratio 1 5.47 (0.66–45.70) 4.34 (0.49–38.13)
All-cause mortality    
 Events and rate (per 1000 patient-years) 11 (15.0) 16 (20.7) 14 (16.6)
 Adjusted hazard ratio 1 1.63 (0.75–3.51) 1.61 (0.72–3.61)
Aged 71–85 years (patient-years) 139 (940) 127 (829) 114 (741)
Clinical albuminuria    
 Events and rate (per 1000 patient-years) 24 (25.5) 28 (33.8) 30 (40.5)
 Adjusted hazard ratio 1 1.10 (0.64–1.90) 1.46 (0.85–2.51)
eGFR <30 mL/[min · 1.73 m2]    
 Events and rate (per 1000 patient-years) 19 (20.2) 16 (19.3) 18 (24.3)
 Adjusted hazard ratio 1 0.95 (0.50–1.81) 1.00 (0.51–1.94)
End-stage renal disease    
 Events and rate (per 1000 patient-years) 7 (7.45) 3 (3.62) 5 (6.75)
 Adjusted hazard ratio 1 0.44 (0.11–2.75) 0.87 (0.28–2.75)
All-cause mortality    
 Events and rate (per 1000 patient-years) 44 (46.8) 27 (32.6) 34 (45.9)
 Adjusted hazard ratio 1 0.68 (0.42–1.10) 1.04 (0.66–1.63)
  1. Abbreviations: HbA1c Glycated hemoglobin, eGFR Estimated glomerular filtration rate.
  2. Adjusted for sex, duration of diabetes, body mass index, smoking status, blood pressure, total cholesterol, HDL cholesterol, serum creatinine, urine albumin-to-creatinine ratio, and medications.