Table 1 Baseline characteristics according to the age groups in type 2 diabetic patients
41-60 years | 61-70 years | 71-75 years | 76-85 years | P value | |
|---|---|---|---|---|---|
Number | 184 | 157 | 194 | 186 | |
Age (years) | 52.3 ± 5.4 | 66.7 ± 2.8 | 72.9 ± 1.4 | 77.9 ± 2.0 | <0.001 |
Sex (men/women) | 85/99 | 84/73 | 160/34 | 167/19 | <0.001 |
Diabetes duration (years) | 6.4 ± 5.7 | 9.4 ± 7.2 | 11.6 ± 8.6 | 12.3 ± 8.3 | 0.001 |
Current smokers (%) | 19.3 | 16.9 | 20.4 | 17.9 | 0.851 |
BMI (Kg/m2) | 26.2 ± 4.2 | 26.0 ± 3.5 | 25.4 ± 3.4 | 24.7 ± 3.1 | 0.004 |
Systolic blood pressure (mmHg) | 137.2 ± 17.2 | 141.8 ± 18.7 | 143.3 ± 19.2 | 141.5 ± 18.5 | 0.070 |
Diastolic blood pressure (mmHg) | 82.3 ± 10.3 | 78.3 ± 11.2 | 75.2 ± 10.5 | 72.3 ± 10.6 | 0.001 |
Fasting plasma glucose (mg/dL) | 163.4 ± 48.4 | 164.7 ± 44.7 | 161.0 ± 44.8 | 164.3 ± 41.3 | 0.876 |
HbA1c (%) | 8.00 ± 1.81 | 7.91 ± 1.66 | 7.88 ± 1.62 | 7.77 ± 1.53 | 0.624 |
Total cholesterol (mg/dL) | 204.9 ± 40.2 | 197.3 ± 38.5 | 198.4 ± 36.4 | 191.2 ± 39.0 | 0.051 |
High density cholesterol (mg/dL) | 34.3 ± 9.2 | 37.6 ± 5.9 | 47.6 ± 8.9 | 45.3 ± 12.3 | 0.013 |
Triglyceride (mg/dL), median (interquartile range) | 160 (98-233) | 145 (96-220) | 125 (86-191) | 123 (85-194) | 0.071 |
Serum creatinine (mg/dL) | 1.03 ± 0.32 | 1.15 ± 0.46 | 1.22 ± 0.40 | 1.30 ± 0.52 | 0.001 |
eGFR (mL/min per1.73 m2) | 75.5 ± 23.1 | 65.1 ± 17.7 | 64.6 ± 20.5 | 60.8 ± 17.2 | 0.001 |
Urine albumin-to-creatinine ratio (mg/g), median (interquartile range) | 17.5 (7.5-115.7) | 18.8 (8.1-113.8) | 31.6 (11.0-125.1) | 24.6 (12.9-106.7) | 0.293 |
Glucose lowering treatment | |||||
Insulin (%) | 35.1 | 29.3 | 40.2 | 26.0 | 0.150 |
Sulfonylureas (%) | 62.6 | 69.9 | 61.5 | 57.3 | 0.339 |
Metformin (%) | 73.3 | 70.7 | 64.1 | 57.3 | 0.069 |
Thiazolidinediones (%) | 13.0 | 15.4 | 8.5 | 8.3 | 0.383 |
Other (%) | 10.7 | 14.6 | 17.1 | 10.4 | 0.354 |
Cardiovascular medication | |||||
ACE inhibitor or ARB (%) | 48.1 | 50.4 | 59.8 | 59.3 | 0.110 |
Calcium channel blocker (%) | 33.6 | 44.7 | 51.3 | 61.5 | 0.007 |
Beta-blocker (%) | 28.2 | 26.8 | 29.9 | 34.4 | 0.658 |
Diuretics (%) | 16.0 | 24.4 | 33.3 | 24.6 | 0.183 |
Statin (%) | 29.8 | 28.5 | 21.4 | 15.6 | 0.064 |
Fibrate (%) | 2.3 | 3.1 | 1.0 | 2.1 | 0.143 |
Aspirin (%) | 23.7 | 32.5 | 43.6 | 43.8 | 0.002 |