After 10 weeks, C57/Bl6 mice on a high fat diet display a significant increase in body weight and a diabetic phenotype characterized by hyperglycemia and fasting hyperinsulinemia. The average weight of the animals receiving a HFD is noticeably and significantly increased already after 1 week and continues to increase over 10 weeks (A) . The average daily food intake (B) is slightly, but significantly, lower in the same group. Fasting blood glucose (C) and HbA1c(D), as well as fasting insulin (E) levels were significantly higher in mice receiving HFD; 33%, 15% and 70% increase, respectively (n = 16 for control diet group, n = 16 for HFD group). Bars represent mean ± SEM. ***, p < 0.001 compared with control group. Statistical analysis was performed using Student’s t-test.