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Table 3 Plasma insulin level

From: Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model

Plasma insulin (ng/ml)

Group

Dose (mg/kg)

Pre-induction

Post-induction

Week-4

% change after treatment

(Mean + SE)

(Mean + SE)

(Mean + SE)

Vehicle (-alloxan)

0

1.25 ± 0.27

1.23 ± 0.29

4.26 ± 0.36

246.3 ↑

UP780 (-)

2000

0.99 ± 0.14

0.99 ± 0.27

4.12 ± 0.39

316.2 ↑

Vehicle (+alloxan)

0

1.78 ± 0.27

1.50 ± 0.34

1.99 ± 0.24

32.7 ↑

Glyburide (+)

5

1.87 ± 0.33

1.10 ± 0.15

1.76 ± 0.50

60.0 ↑

UP780 (+)

2000

1.96 ± 0.31

1.48 ± 0.33

2.37 ± 0.41

60.1 ↑

UP394 (+)

80

2.48 ± 0.5

1.68 ± 0.48

1.60 ± 0.37

4.8 ↓

Qmatrix (+)

1920

1.89 ± 0.28

1.50 ± 0.21

1.69 ± 0.32

12.7 ↑

  1. Insulin dependent diabetes was induced by administering a single intraperitoneal injection of alloxan monohydrate at a dose of 150 mg/kg to CD-1 mice. Measurements for plasma insulin were taken at pre-induction, week-0 (baseline), and week-4 after treatment. Data are expressed as mean ± SD as well as percent change of treatment. ↑ increase from post induction, ↓ decrease from post induction.
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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