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Table 5 Association between LEPR Gln233Arg, LEP G2548A and BDNF Val66Met polymorphisms and MS

From: Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

SNPs

Genotype frequencies

OR (95% CI)

p-valuea

 

MS n (%)

Control n (%)

  

LEPR Gln223Arg

    

Genotype

    

Arg/Arg + Arg/Gln

100 (62.5)

79 (48.8)

1.8 (1.2-2.7)

0.013*

Gln/Gln

60 (37.5)

83 (51.2)

  

LEP G2548A

    

Genotype

    

A/A + A/G

137 (85.6)

130 (80.2)

1.5 (0.8-2.6)

0.200

G/G

23 (14.4)

32 (19.8)

  

BDNF Val66Met

    

Genotype

    

Met/Met + Met/Val

116 (72.5)

105 (64.8)

1.4 (0.8-2.5)

0.230

Val/Val

44 (27.5)

57 (35.2)

  
  1. Abbreviation: LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
  2. Significant level;* = p < 0.05.
  3. aBased on the results of chi-square test.