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Table 5 Association between LEPR Gln233Arg, LEP G2548A and BDNF Val66Met polymorphisms and MS

From: Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

SNPs Genotype frequencies OR (95% CI) p-valuea
  MS n (%) Control n (%)   
LEPR Gln223Arg     
Genotype     
Arg/Arg + Arg/Gln 100 (62.5) 79 (48.8) 1.8 (1.2-2.7) 0.013*
Gln/Gln 60 (37.5) 83 (51.2)   
LEP G2548A     
Genotype     
A/A + A/G 137 (85.6) 130 (80.2) 1.5 (0.8-2.6) 0.200
G/G 23 (14.4) 32 (19.8)   
BDNF Val66Met     
Genotype     
Met/Met + Met/Val 116 (72.5) 105 (64.8) 1.4 (0.8-2.5) 0.230
Val/Val 44 (27.5) 57 (35.2)   
  1. Abbreviation: LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
  2. Significant level;* = p < 0.05.
  3. aBased on the results of chi-square test.