Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

Table 4 Genotypic and allelic distribution of LEPR Gln233Arg, LEP G2548A, and BDNF Val66Met polymorphisms in MS and control subjects

	MS n (%)	HWE of MS p-value^a	Control n (%)	HWE of control p-value*	Genotypic or allelic p-value^b
*LEPR* Gln233Arg
Genotype
Arg/Arg	20 (12.5)	0.399	17 (10.5)	0.295	0.044*
Arg/Gln	80 (50.0)	(df = 1)	62 (38.3)	(df = 1)
Gln/Gln	60 (37.5)	(χ² = 0.71)	83 (51.2)	(χ² = 1.09)
Allele
Arg	120 (0.375)		96 (0.296)		0.034*
Gln	200 (0.625)		228 (0.704)		0.034*
*LEP* G2548A
Genotype
A/A	58 (36.2)	0.638	55 (34.0)	0.483	0.439
A/G	79 (49.4)	(df = 1)	75 (46.3)	(df = 1)
G/G	23 (14.4)	(χ² = 0.22)	32 (19.7)	(χ² = 0.49)
Allele
A	195 (0.609)		185 (0.571)		0.321
G	125 (0.391)		139 (0.429)		0.321
*BDNF* Val66Met
Genetype
Met/Met	32 (20.0)	0.479	30 (18.5)	0.544	0.327
Met/Val	84 (52.5)	(df = 1)	75 (46.3)	(df = 1)
Val/Val	44 (27.5)	(χ² = 0.50)	57 (35.2)	(χ² = 0.37)
Allele
Met	148 (0.463)		135 (0.417)		0.241
Val	172 (0.537)		189 (0.583)

Abbreviation: HWE Hardy-Weinberg equilibrium, LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
Significant level;* = p < 0.05.
^aBased on the results of chi-square test.
^bBased on the results of chi-square test for the comparison between MS and control groups.

ISSN: 1758-5996