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Table 4 Genotypic and allelic distribution of LEPR Gln233Arg, LEP G2548A, and BDNF Val66Met polymorphisms in MS and control subjects

From: Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

  MS n (%) HWE of MS p-valuea Control n (%) HWE of control p-value* Genotypic or allelic p-valueb
LEPR Gln233Arg
Genotype
Arg/Arg 20 (12.5) 0.399 17 (10.5) 0.295 0.044*
Arg/Gln 80 (50.0) (df = 1) 62 (38.3) (df = 1)
Gln/Gln 60 (37.5) 2 = 0.71) 83 (51.2) 2 = 1.09)
Allele
Arg 120 (0.375)   96 (0.296)   0.034*
Gln 200 (0.625)   228 (0.704)  
LEP G2548A
Genotype
A/A 58 (36.2) 0.638 55 (34.0) 0.483 0.439
A/G 79 (49.4) (df = 1) 75 (46.3) (df = 1)
G/G 23 (14.4) 2 = 0.22) 32 (19.7) 2 = 0.49)
Allele
A 195 (0.609)   185 (0.571)   0.321
G 125 (0.391)   139 (0.429)  
BDNF Val66Met
Genetype
Met/Met 32 (20.0) 0.479 30 (18.5) 0.544 0.327
Met/Val 84 (52.5) (df = 1) 75 (46.3) (df = 1)
Val/Val 44 (27.5) 2 = 0.50) 57 (35.2) 2 = 0.37)
Allele
Met 148 (0.463)   135 (0.417)   0.241
Val 172 (0.537)   189 (0.583)   
  1. Abbreviation: HWE Hardy-Weinberg equilibrium, LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
  2. Significant level;* = p < 0.05.
  3. aBased on the results of chi-square test.
  4. bBased on the results of chi-square test for the comparison between MS and control groups.