Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

Table 3 Adjusted odds ratio for LEPR Gln223Arg, LEP G2548A and BDNF Val66Met polymorphisms with leptin level, BDNF level and metabolic features

Variables	SNPLEPR Gln223Arg	p-value	SNPLEP G2548A	p-value	SNPBDNF Val66Met	p-value
	OR (95% CI)		OR (95% CI)		OR (95% CI)
Systolic BP	0.989 (0.952-1.027)	0.568	1.030 (0.982-1.090)	0.318	1.022 (0.978-1.068)	0.331
Diastolic BP	1.019 (0.968-1.072)	0.474	1.000 (0.932-1.073)	0.999	1.017 (0.972-1.075)	0.447
WC	0.991 (0.972-1.046)	0.437	1.044 (0.966-1.129)	0.270	0.968 (0.899-1.043)	0.410
TG	0.999 (0.993-1.004)	0.635	1.002 (0.994-1.009)	0.636	0.998 (0.991-1.007)	0.378
HDL-C	1.000 (0.974-1.038)	0.994	0.992 (0.945-1.041)	0.745	1.002 (0.965-1.029)	0.722
Glucose	1.047 (1.004-1.092)	0.033*	1.021 (0.989-1.065)	0.340	0.989 (0.965-1.019)	0.354
Insulin	1.016 (0.997-1.056)	0.099	0.985 (0.944-1.027)	0.473	1.009 (0.972-1.050)	0.600
Leptin	1.192 (1.038-1.379)	0.009**	0.924 (0.816-1.039)	0.209	0.963 (0.873-1.050)	0.903
BDNF	0.997 (0.950-1.045)	0.737	0.986 (0.925-1.051)	0.576	0.980 (0.943-1.045)	0.909

Abbreviation: BDNF Brain-derived neurotrophic factor, TG triglyceride, HDL-C high-density lipoprotein cholesterol.
WC waist circumference, LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
Significant levels;* = p < 0.05, **= p < 0.01.

ISSN: 1758-5996