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Table 3 Adjusted odds ratio for LEPR Gln223Arg, LEP G2548A and BDNF Val66Met polymorphisms with leptin level, BDNF level and metabolic features

From: Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

Variables SNPLEPR Gln223Arg p-value SNPLEP G2548A p-value SNPBDNF Val66Met p-value
  OR (95% CI)   OR (95% CI)   OR (95% CI)  
Systolic BP 0.989 (0.952-1.027) 0.568 1.030 (0.982-1.090) 0.318 1.022 (0.978-1.068) 0.331
Diastolic BP 1.019 (0.968-1.072) 0.474 1.000 (0.932-1.073) 0.999 1.017 (0.972-1.075) 0.447
WC 0.991 (0.972-1.046) 0.437 1.044 (0.966-1.129) 0.270 0.968 (0.899-1.043) 0.410
TG 0.999 (0.993-1.004) 0.635 1.002 (0.994-1.009) 0.636 0.998 (0.991-1.007) 0.378
HDL-C 1.000 (0.974-1.038) 0.994 0.992 (0.945-1.041) 0.745 1.002 (0.965-1.029) 0.722
Glucose 1.047 (1.004-1.092) 0.033* 1.021 (0.989-1.065) 0.340 0.989 (0.965-1.019) 0.354
Insulin 1.016 (0.997-1.056) 0.099 0.985 (0.944-1.027) 0.473 1.009 (0.972-1.050) 0.600
Leptin 1.192 (1.038-1.379) 0.009** 0.924 (0.816-1.039) 0.209 0.963 (0.873-1.050) 0.903
BDNF 0.997 (0.950-1.045) 0.737 0.986 (0.925-1.051) 0.576 0.980 (0.943-1.045) 0.909
  1. Abbreviation: BDNF Brain-derived neurotrophic factor, TG triglyceride, HDL-C high-density lipoprotein cholesterol.
  2. WC waist circumference, LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
  3. Significant levels;* = p < 0.05, **= p < 0.01.