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Table 1 Levels and descriptions of evidence

From: Diabetes and cardiovascular disease: from evidence to clinical practice – position statement 2014 of Brazilian Diabetes Society

Levels of evidence Description
Level A Direct evidence from meta-analysis or randomized clinical trials
Level B Evidence from large observational studies and indirect evidence analysis of pre-specified subgroup of randomized clinical trials or meta-analysis with low heterogeneity.
Level C Evidence from small studies, non-randomized or open
Level D Expert opinion