Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats

Table 3 Resting anaesthetised haemodynamic parameters obtained before the administration of vasoactive substances

Group	SBP	DBP	MAP	PP	HR	Peak dP/dt	PWV
Group	(mmHg)	(mmHg)	(mmHg)	(mmHg)	(beats/min)	(mmHg/s)	(m/s)
Control	155 ± 15^#	113 ± 15^#	130 ± 28^#	41 ± 3	462 ± 46	4024 ± 617	4.5 ± 0.5^#
Diabetes	142 ± 13^#	105 ± 13^#	124 ± 14^#	38 ± 9	386 ± 48^*#	2186 ± 198^*#	4.6 ± 0.9^#
Diabetes + telmisartan	110 ± 14	75 ± 14	92 ± 12	35 ± 5	321 ± 26^*	3294 ± 183^*	3.6 ± 0.3

SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; HR, heart rate; dP/dt, maximal change in pressure over time; PWV, pulse wave velocity.
^*P <0.01 vs Control; ^#P <0.01 vs Diabetes + telmisartan.

ISSN: 1758-5996