Table 1 3-month parameter including donor- and recipient characteristics as well as graft, cardiovascular and metabolic outcomes
NGR (n = 43) | IFG/IGT (n = 26) | PTDM (n = 14) | P-value* | |
|---|---|---|---|---|
Donor characteristics | ||||
Live donor, % | 48.8 | 57.7 | 35.7 | 0.41 |
Age in years, mean (SD) | 46.8 (16.8) | 51.0 (12.4) | 53.3 (12.0) | 0.29 |
Recipient characteristics | ||||
Age in years, mean (SD) | 49.5 (14.0) | 54.2 (11.4) | 51.1 (8.0) | 0.27 |
Male, % | 30.2 | 38.5 | 64.3 | 0.08 |
Body mass index in kg/m2, mean (SD) | 27.2 (5.2) | 26.7 (4.0) | 25.1 (3.9) | 0.60 |
Time on dialysis in years, mean (SD) | 2.9 (2.8) | 2.9 (3.3) | 2.1 (2.3) | 0.67 |
Dialysis modality, % | 0.44 | |||
-HD | 44.2 | 46.2 | 42.9 | |
-PD | 34.9 | 42.3 | 21.4 | |
-Preemptive | 20.9 | 11.5 | 35.7 | |
HLA mismatch out of 6, mean (SD) | 3.0 (1.7) | 3.7 (1.5) | 3.4 (1.4) | 0.21 |
Peak PRA, % | 21.9 | 9.9 | 31.6 | 0.12 |
Prevalent hypertension, % | 30 | 25 | 34 | 0.88 |
Prevalent cardiovascular disease, % | 5 | 10 | 8 | 0.52 |
Immunosuppression | ||||
Tacrolimus, % | 70 | 46 | 71 | 0.18 |
Steroid dose in mg/d, mean (SD) | 10.2 (2.2) | 9.2 (1.7) | 9.6 (0.9) | 0.10 |
Graft outcomes | ||||
eGFR in ml/min/1.73 m2, mean (SD) | 52.2 (17.1) | 51.0 (20.3) | 48.0 (16.6) | 0.75 |
Acute rejection, %** | 4.7 | 7.7 | 0.0 | 0.55 |
Spot urine protein/creatinine ratio in mg/g, mean (SD) | 20.1 (22.0) | 55.2 (83.0) | 62.1 (87.1) | 0.23 |
Cardiovascular outcomes | ||||
Beta-blocker, % | 37.2 | 50.0 | 42.9 | 0.58 |
ACE-I, % | 23.3 | 38.5 | 35.7 | 0.36 |
ARB, % | 11.6 | 15.4 | 21.4 | 0.65 |
Calcium channel blockers, % | 23.3 | 38.5 | 42.9 | 0.25 |
Number of antihypertensive agents, mean (SD) | 1.0 (0.9) | 1.4 (0.9) | 1.4 (0.9) | 0.16 |
Statin, % | 34.9 | 46.2 | 78.6 | 0.02 |
Aspirin, % | 18.6 | 19.2 | 35.7 | 0.37 |
Systolic BP in mmHg, mean (SD) | 141.1 (16.0) | 139.0 (14.8) | 132.7 (12.8) | 0.20 |
Diastolic BP in mmHg, mean (SD) | 77.6 (13.9) | 80.4 (7.5) | 79 (8.8) | 0.62 |
AIx in %, mean (SD) | 19.1 (11.6) | 22.9 (6.8) | 26.4 (6.7) | 0.04 |
Aortic PWV in m/s, mean (SD) | 7.1 (1.6) | 7.9 (2.4) | 7.8 (2.3) | 0.21 |
Metabolic outcomes | ||||
Cholesterol in mg/dl (SD) | 5.2 (1.7) | 5.7 (1.0) | 4.6 (0.9) | 0.07 |
Triglyceride in mg/dl (SD) | 2.3 (2.3) | 2.2 (0.9) | 2.0 (0.5) | 0.90 |
HOMA-IR, mean (SD) | 1.83 (1.11) | 1.85 (0.71) | 2.48 (1.25) | 0.26 |
HOMA-% beta, mean (SD) | 0.03 (0.2) | 0.03 (0.01) | 0.03 (0.01) | 0.35 |
Albumin-adjusted Calcium in mmol/l, mean (SD) | 2.5 (0.1) | 2.6 (0.2) | 2.5 (0.2) | 0.08 |
Phosphate in mmol/l, mean (SD) | 0.90 (0.23) | 0.79 (0.18) | 0.80 (0.26) | 0.12 |
Hemoglobin in g/l, mean (SD) | 122 (19) | 119 (15) | 114 (18) | 0.34 |