Effect of combination treatment of S–amlodipine with peroxisome proliferator-activated receptor agonists on metabolic and cardiovascular parameters in Zucker fa/fa rats

Table 1 Effect of combination of S-Amlodipine with Ragaglitazar and Pioglitazone on biochemical parameters in Zucker fa/fa rats

	Glucose (mg/dl)	TC (mg/dl)	TG (mg/dl)	Creatinine
Control	115.18 ± 6.64	139.08 ± 14.55	362.56 ± 47.53	0.88 ± 0.08
S-Amlodipine	89.71 ± 2.72*	134.94 ± 12.89	267.75 ± 17.15	0.78 ± 0.12
Pioglitazone	90.60 ± 2.11*	146.50 ± 4.10	230.64 ± 18.81**	0.76 ± 0.04
Ragaglitazar	106.45 ± 1.55	133.58 ± 2.59	173.21 ± 15.70**	0.77 ± 0.08
S-Amlo + Pio	81.76 ± 4.24*^$	131.97 ± 10.03	211.14 ± 23.78**	0.80 ± 0.05
S-Amlo + Raga	103.01 ± 7.48	148.34 ± 14.47	252.34 ± 27.86*	0.79 ± 0.04

Data are shown as means ± S.E.M. n = 7 per group. *significantly different from the control (*p < 0.05, **p < 0.01); (^$p < 0.05; one-tailed ‘t’ test; Pio vs. Amlo + Pio). Amlo, Amlodipine; Pio, Pioglitazone; Raga, Ragaglitazar.

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