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Table 1 Effect of combination of S-Amlodipine with Ragaglitazar and Pioglitazone on biochemical parameters in Zucker fa/fa rats

From: Effect of combination treatment of S–amlodipine with peroxisome proliferator-activated receptor agonists on metabolic and cardiovascular parameters in Zucker fa/fa rats

  Glucose (mg/dl) TC (mg/dl) TG (mg/dl) Creatinine
Control 115.18 ± 6.64 139.08 ± 14.55 362.56 ± 47.53 0.88 ± 0.08
S-Amlodipine 89.71 ± 2.72* 134.94 ± 12.89 267.75 ± 17.15 0.78 ± 0.12
Pioglitazone 90.60 ± 2.11* 146.50 ± 4.10 230.64 ± 18.81** 0.76 ± 0.04
Ragaglitazar 106.45 ± 1.55 133.58 ± 2.59 173.21 ± 15.70** 0.77 ± 0.08
S-Amlo + Pio 81.76 ± 4.24*$ 131.97 ± 10.03 211.14 ± 23.78** 0.80 ± 0.05
S-Amlo + Raga 103.01 ± 7.48 148.34 ± 14.47 252.34 ± 27.86* 0.79 ± 0.04
  1. Data are shown as means ± S.E.M. n = 7 per group. *significantly different from the control (*p < 0.05, **p < 0.01); ($p < 0.05; one-tailed ‘t’ test; Pio vs. Amlo + Pio). Amlo, Amlodipine; Pio, Pioglitazone; Raga, Ragaglitazar.