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Table 1 Characteristics of study participants with normal liver fat content (IHL ≤ 5.5%) versus those with elevated liver fat (IHL > 5.5%)

From: Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals

Variable

IHL ≤5.5%

IHL >5.5%

p

 

Mean

± SD

Mean

± SD

p

M:F

20:21

-

19:10

-

 

Age (years)

71.5

2.6

71.0

2.2

0.48

Weight (Kg)

70.1

11.3

84.4

12.7

<0.001

BMI (kg m-2)

25.2

2.7

28.6

3.6

<0.001

Waist (cm)

91.1

10.2

104.6

9.4

<0.001

MRI VAT (cm2)

93.1

48.5

176.5

55.9

<0.001

Alcohol (units/week)*

2.0

(1.0,6.0)

2.0

(0,14.0)

0.88

ALT (iu/l)*

21.0

(17.0,27.0)

32.0

(24.0,36.0)

<0.001

HbA1c (%)

5.6

0.3

5.7

0.3

0.20

HIE (%)

88.1

2.8

85.6

4.5

0.01

OGIS (ml min-1 m-2)

438.6

52.1

367.8

52.4

<0.001

IHL (%)*

1.8

(0.9,3.4)

14.6

(7.9,19.0)

<0.001

SBP (mmHg)

135.4

18.0

139.2

17.0

0.38

DBP (mmHg)

74.2

8.8

76.0

10.2

0.44

Fasting Glucose (mmol/l)

4.9

0.4

5.2

0.5

0.028

2-hour Glucose (mmol/l)

6.5

1.7

8.2

1.8

<0.001

Fasting Insulin (pmol/l)*

47.0

(32.8,64.6)

77.3

(48.1,102.0)

<0.001

Total Cholesterol (mmol/l)

5.8

1.1

5.3

1.2

0.12

HDL-Cholesterol (mmol/l)

1.6

0.4

1.3

0.3

0.007

LDL-Cholesterol (mmol/l)

3.7

0.9

3.3

1.0

0.039

Triglycerides (mmol/l)*

1.0

(0.7,1.3)

1.5

(1.0,2.4)

<0.001

zMS

-0.40

0.49

0.34

0.44

<0.001

Taking statin (%)

4 (9.8%)

 

10 (34.5%)

 

0.011

Taking ACEI/ARB (%)

7 (17.1%)

 

7 (24.1%)

 

0.47

Taking Betablocker (%)

5 (12.2%)

 

7 (24.1%)

 

0.19

Taking CCB (%)

4 (9.8%)

 

6 (20.7%)

 

0.20

Family History of DM (%)

10 (25%)

 

7 (25.9%)

 

0.93

Current or ex-smoker (%)

12 (29.3%)

 

12 (41.4%)

 

0.29

  1. Continuous variables are summarised as means ± standard deviations, with p-values from t-tests. Continuous variables asterisked (*) have skewed distributions, so are summarised are medians and interquartile ranges, with p-values from Wilcoxon rank sum tests. Binary variables are summarised as N and %, with p-values from chi-squared tests.
  2. ACEI – Angiotensin Converting Enzyme Inhibitor; ARB – Angiotensin Receptor Blocker; CCB – Calcium Channel Blocker; DBP – Diastolic Blood Pressure; DM – Diabetes Mellitus; HDL – High Density Lipoprotein; HIE – Hepatic Insulin Extraction; IHL – Intrahepatic Lipid; LDL – Low Density Lipoprotein; OGIS – oral glucose insulin sensitivity; SBP – Systolic Blood Pressure; zMS – Standardised Composite Metabolic Risk.