Serum metabolic profiles in overweight and obese women with and without metabolic syndrome

Table 2 Mean metabolite factor levels in MHO and MetS groups

Factor	MHO n = 42		MetS n = 36		p-value	adj p-value
1) Amino acids and glycoproteins	−0.34	(0.98)	0.43	(0.86)	0.001	0.001
2) Fatty acids and phospholipids	−0.31	(0.82)	0.39	(1.08)	0.003	0.002
3) PUFA	−0.16	(1.06)	0.21	(0.89)	0.120	0.631
4) Ketone bodies	0.07	(1.05)	−0.09	(0.94)	0.497	0.377
5) Gluconeogenic intermediates	0.06	(0.97)	−0.08	(1.04)	0.555	0.944
6) Miscellaneous	0.04	(0.97)	−0.05	(1.05)	0.726	0.464
7) Miscellaneous	0.08	(0.99)	−0.10	(1.01)	0.431	0.700
8) Miscellaneous	0.15	(0.75)	−0.18	(1.23)	0.167	0.228

MHO = metabolically healthy overweight/obese; MetS = metabolic syndrome. Values are given as mean (SD); Factor 1(leucine, isoleucine, valine, tyrosine, phenylalanine, orosomucoid); Factor 2 (total fatty acids, omega-6 fatty acids, omega7 and 9 fatty acids, linoleic acid, mono-unsaturated fatty acids, total phosphoglycerides, total phosphocholines); Factor 3 (docosahexaenoic acid, polyunsaturated fatty acids, omega-3 fatty acids); Factor 4 (acetoacetate, 3-hydroxybutyrate); Factor 5 (glutamine, glycine, pyruvate); Factor 6 (acetate, histidine); Factor 7 (creatinine, citrate); Factor 8 (urea). P-values are for the difference in mean metabolite factor levels between MHO and MetS groups with and without adjustment for age, fat mass and waist circumference.

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